Duplication of a germline promoter downstream of the IgH 3

Duplication of a germline promoter downstream of the IgH 3 - Nature

During an adaptive immune response, B cells can change their surface immunoglobulins from IgM to IgG, IgE or IgA through a process called ...

Duplication of a germline promoter downstream of the IgH 3 - OUCI

Duplication of a germline promoter downstream of the IgH 3′ regulatory region impairs class switch recombination · Joana M. Santos · Fatima-Zohra Braikia · Chloé ...

Duplication of a germline promoter downstream of the IgH 3 ... - BVS

Duplication of a germline promoter downstream of the IgH 3' regulatory region impairs class switch recombination. Santos, Joana M; Braikia, Fatima-Zohra; ...

Germline deletion of Igh 3′ regulatory region elements hs5-7 ...

Dark circle identifies origin of replication for Igh CH genes (66). B, One of 3 experiments, analyzing expression levels over time for downstream genes in WT ...

Replacement of Iγ3 germ-line promoter by Iγ1 inhibits class-switch ...

... upstream of the GL promoters or downstream of the IgH locus. How the 3′RR effects its long-range activation is presently unclear. Essentially four models ...

Elucidation of a downstream boundary of the 3′ IgH regulatory region

This further supported a model whereby “interaction” with the 3′ IgH RR is required for the activity to the germline promoters (“I exon promoters”) associated ...

Inducible CTCF insulator delays the IgH 3′ regulatory region ...

... IgH 3′ regulatory region-mediated activation of germline promoters ... Duplication of Iα GL promoter downstream of the 3′RR. (A) Scheme of ...

Two modes of cis-activation of switch transcription by the IgH ... - PNAS

To explore whether the 3′RR displays a bidirectional activity, we used a mouse line in which the Iα promoter has been duplicated downstream of ...

Elucidation of a downstream boundary of the 3′ IgH regulatory ...

The 30kb region just downstream of the most 3' C(H) gene ... Duplication of a germline promoter downstream of the IgH 3′ regulatory region impairs class switch ...

Structure and expression of mouse germline immunoglobulin γ3 ...

Duplication of a germline promoter downstream of the IgH 3′ regulatory region impairs class switch recombination. Article Open access 15 June 2018 ...

The IgH Locus 3′ Regulatory Region: Pulling the Strings from Behind

Cytokines exquisitely tune CSR through a regulation of germline transcription (GT) from I promoters of IgH constant (C) genes, which is known as a prerequisite ...

Regulation of Transcription of the Germline Immunoglobulin α ...

Duplication of a germline promoter downstream of the IgH 3′ regulatory region impairs class switch recombination. Article Open access 15 June 2018. The ...

Genomic deletion of the whole IgH 3′ regulatory region (hs3a, hs1 ...

... gene with a downstream CH gene. Finally, plasma cell differentiation ... The germline transcript promoter association with the Eμ-3′RR complex might ...

Regulation of the promoter for human immunoglobulin q 3 germ-line ...

Insertion of DNA segments from the human 3' IgH regions, which may function as a locus control region for switch recombi- nation, greatly activated the promoter ...

Regulation of Germline Promoters by the Two Human Ig Heavy ...

Abstract. The human IgH 3′ enhancers, located downstream of each of the two Cα genes, modulate germline (GL) transcription of the IgH genes ...

IgH Locus Elements that Effect Long-Distance Regulation of Class ...

... germline transcription promoters from the downstream part of the LCR. We ... 3′ IgH/hs1,2 enhancer downstream the human immunoglobulin α1 gene. Eur. J ...

Elucidation of IgH 3′ region regulatory role during class switch ...

In mature B cells, class switch recombination (CSR) replaces the expressed constant Cμ gene with a downstream CH gene.

Long-Range Control of Class Switch Recombination by ... - Frontiers

Duplication of a Germline Promoter Downstream of the IgH 3' Regulatory Region Impairs Class Switch Recombination. Sci Rep (2018) 8:9164. doi: 10.1038/s41598 ...

Inducible CTCF insulator delays the IgH 3' regulatory region ...

Duplication of a germline promoter downstream of the IgH 3′ regulatory region impairs class switch recombination. Article. Full-text available. Jun 2018.

Mechanism and regulation of class switch recombination by IgH ...

Accordingly, duplication of Iα promoter downstream ... Duplication of a germline promoter downstream of the IgH 3' regulatory region impairs class ...