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Dynamic incorporation of multiple in silico functional annotations ...


Dynamic incorporation of multiple in silico functional annotations ...

Large-scale whole-genome sequencing studies have enabled the analysis of rare variants (RVs) associated with complex phenotypes.

Dynamic incorporation of multiple in silico functional ... - PubMed

Large-scale whole-genome sequencing studies have enabled the analysis of rare variants (RVs) associated with complex phenotypes.

Dynamic incorporation of multiple in silico functional annotations ...

We propose STAAR (variant-Set Test for Association using Annotation infoRmation), a scalable and powerful RVAT method that effectively ...

Dynamic incorporation of multiple in silico functional annotations ...

Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole- genome sequencing studies at ...

Dynamic incorporation of multiple in silico functional annotations ...

Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale.

Dynamic incorporation of multiple in silico functional annotations ...

For the latter, we introduce 'annotation principal components', multidimensional summaries of in silico variant annotations. STAAR accounts for population ...

Dynamic incorporation of multiple in silico functional annotations ...

The STAAR package accompanies the paper “Dynamic incorporation of multiple in silico functional annotations empowers rare variant ...

Dynamic incorporation of multiple in silico functional annotations ...

Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing ...

Dynamic incorporation of multiple in silico functional annotations ...

Dive into the research topics of 'Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole- ...

Dynamic incorporation of multiple in silico functional annotations ...

Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at ...

Nature Genetics on X: "Dynamic incorporation of multiple in silico ...

Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome ...

STAARpipeline apps: Enhancing Rare Variant Analysis in Whole ...

Association analysis power is increased by dynamically incorporating functional annotations. Additional strategies for grouping noncoding ...

FAVOR - (Functional Annotation of Variants Online Resource)

Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale.

Scalable approaches for functional analyses of whole-genome ...

S. et al. (. 2020. ) Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome ...

xihaoli/STAAR: An R package for performing STAAR ... - GitHub

Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale.

Talks

Dynamic incorporation of multiple in-silico functional annotations empowers rare variant association analysis of large-scale whole genome sequencing studies

a cloud-based workflow for scalable and reproducible rare variant ...

(2020) Dynamic incorporation of multiple in silico functional annotations empowers rare variant associ- ation analysis of large whole-genome ...

A statistical framework for powerful multi-trait rare variant analysis in ...

By dynamically incorporating multiple annotations capturing diverse aspects of variant biological function in the second step, MultiSTAAR ...

Rare variants in long non-coding RNAs are associated with blood ...

41. Li, X. ∙ Li, Z. ∙ Zhou, H. ... Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole- ...

Papers

Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale.