Dynamic regulation of RNA editing in human brain development and ...

Here we surveyed the global landscape of RNA editing in human brain tissues and identified three unique patterns of A-to-I RNA editing rates during cortical ...

DYNAMIC REGULATION OF RNA EDITING IN HUMAN BRAIN ...

These processes affect most cellular RNAs including messenger RNA. (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA), as well as small RNA such as. miRNA.

RNA editing is increasingly recognized as a molecular mechanism regulating RNA activity and recoding proteins. Here, I surveyed the global landscape of RNA ...

Dynamic regulation of RNA editing in human brain development and ...

Three unique patterns of A-to-I RNA editing rates during cortical development are identified: stable high, stable low and increasing, revealing global and ...

Dynamic regulation of RNA editing in human brain development and ...

... ... RNA editing sites are dynamically regulated throughout human cortical development 15, 16 , with marked increases in editing levels occurring between mid- ...

Cellular and genetic drivers of RNA editing variation in the human ...

Posttranscriptional adenosine-to-inosine modifications amplify the functionality of RNA molecules in the brain, yet the cellular and genetic ...

Dynamic regulation of RNA editing in human brain development and ...

RNA editing is increasingly recognized as a molecular mechanism regulating RNA activity and recoding proteins. Here we surveyed the global landscape of RNA ...

Spatiotemporal and genetic regulation of A-to-I editing throughout ...

Adenosine-to-inosine (A-to-I) editing is a major contributor to the global diversity of RNA sequences in the human brain, and is predicted to ...

Dynamic regulation of RNA editing in human brain development and ...

Dynamic regulation of RNA editing in human brain development and disease · List of references · Publications that cite this publication. Post-transcriptional ...

Adenosine-to-inosine RNA editing in neurological development and ...

This reaction is catalysed by enzymes called adenosine deaminases acting on RNA (ADARs). RNA editing is involved in the regulation of protein function and gene ...

Dynamic regulation of RNA editing of ion channels and receptors in ...

The post-transcriptional modification of mammalian transcripts in the central nervous system by adenosine-to-inosine RNA editing is an ...

Spatiotemporal mapping of RNA editing in the developing mouse ...

We found increasing editing diversity throughout development, which arises through regional- and cell type-specific regulation of ADAR enzymes ...

Study provides more nuanced insights into RNA modifications by A ...

Our work provides more nuanced and accurate insights into the contribution of RNA modifications by A-to-I editing during human brain development ...

Expansion of RNA sequence diversity and RNA editing rates ...

Post-transcriptional modifications by RNA editing are essential for neurodevelopment, yet their developmental and regulatory features remain ...

Global RNA editing identification and characterization during human ...

Here, we identified genome-wide RNA editing sites and systemically characterized their genomic distribution during four stages of human cardiomyocyte ...

RNA Editing: A Contributor to Neuronal Dynamics in the Mammalian ...

Recent analyses show a global developmental regulation of A-to-I editing during neuronal maturation. Local distribution of both coding and non-coding RNA ...

Cellular and genetic drivers of RNA editing variation in the human ...

These data reveal an expansive repertoire of highly regulated RNA editing sites across human brain cell types and provide a resolved atlas ...

Adenosine-to-Inosine RNA Editing Within Corticolimbic Brain ...

In contrast, sequencing analysis revealed modest and dynamic regulation of A-to-I editing within numerous transcripts in both the mPFC and BLA ...

RNA Editing: A Contributor to Neuronal Dynamics in the Mammalian ...

... A-to-I RNA editing, a unique type of post-transcriptional modification, presents its diverse roles in brain development and immune regulation to contribute ...

Dynamic Regulation of Adenosine Deamination-Mediated RNA ...

The dynamics of A to I editing are described and the known and likely mechanisms that will lead to global but also substrate-specific regulation of A-to-I ...