Dysregulation of BCL|2 family proteins in blood neoplasm

Dysregulation of BCL-2 family proteins in blood neoplasm

This review explores the regulation of intrinsic apoptosis, the role of PTMs, the imbalance of BCL-2 in blood cancers, the treatment strategy involving ...

BCL2-Family Dysregulation in B-Cell Malignancies - PubMed Central

BCL2-family proteins have a central role in the mitochondrial apoptosis machinery and their expression is known to be deregulated in many cancer types.

Dysregulation of BCL-2 family proteins in blood neoplasm

Article on Dysregulation of BCL-2 family proteins in blood neoplasm: therapeutic relevance of antineoplastic agent venetoclax, published in ...

BCL2-Family Dysregulation in B-Cell Malignancies - PubMed

BCL2-family proteins have a central role in the mitochondrial apoptosis machinery and their expression is known to be deregulated in many ...

Dysregulation Of Bcl2 Family Proteins Induced By JAK2V617F ...

Gene expression analysis revealed that Bcl-xL was upregulated in sorted LSKs (Lin- Sca-1+ cKIThi) containing HSCs but not in the more committed ...

Dysregulation of BCL-2 family proteins by leukemia fusion genes

These genetic rearrangements confer phenotypic hallmarks of malignant transformation, including unrestricted proliferation and a relative resistance to ...

Targeting BCL-2 in B-cell malignancies and overcoming therapeutic ...

Members of the B-cell leukemia/lymphoma-2 (BCL-2) family of proteins are key regulators of the intrinsic, mitochondrial apoptotic pathway.

Dysregulation of BCL-2 family proteins in blood neoplasm - OUCI

During cellular stress, the master regulators of intrinsic self-death (apoptosis) are BCL-2 family proteins. The BCL-2 family proteins play a key role in ...

Bcl-2–family proteins and hematologic malignancies

Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. ,. Blood. ,. 1993. , vol. 81. (pg. 151. -. 157. ) Article.

BCL-2 protein family: attractive targets for cancer therapy | Apoptosis

Acquired resistance to cell death is a hallmark of cancer. The BCL-2 protein family members play important roles in controlling apoptotic ...

The role of BCL-2 family proteins in regulating apoptosis and cancer ...

Consequently, overcoming the resistance of tumor cells to apoptosis by inhibiting the BCL-2 anti-apoptotic protein is a novel therapeutic regimen based on tumor ...

Targeting BCL-2 family proteins using BH3 mimetic drugs for cancer ...

Apoptotic dysfunction may allow cancer cells to survive. Overexpression of anti-apoptotic B cell lymphoma-2 (BCL-2) family protein members is ...

Transcript-Level Dysregulation of BCL2 Family Genes in Acute ...

The expression of apoptosis-related BCL2 family genes, fine-tuned in normal cells, is dysregulated in many neoplasms. In acute myeloid leukemia (AML), this ...

Exploring BCL-2 Inhibitors in Cancer Therapy

As mentioned earlier, BCL2 family proteins were found to have a dysregulated expression in various hematological and solid tumor types, such as B/T-cell ...

Targeting BCL2 for the Treatment of Lymphoid Malignancies

In hematologic malignancies, this impairment of apoptosis is often caused by overexpression of the pro-survival protein BCL2. Because abnormally high levels of ...

BCL-2 as therapeutic target for hematological malignancies

In many cancers, high levels of anti-apoptotic proteins such as BCL-2 and BCL-XL were shown to contribute not only to tumor initiation and ...

The BCL-2 protein family, BH3-mimetics and cancer therapy - Nature

Indeed, many pro-apoptotic members of the BCL-2 family have demonstrated tumour-suppression activity in mouse models of cancer and are lost or ...

The mitochondrial anti-apoptotic dependencies of hematologic ...

As a general feature of blood cancers, different antiapoptotic members of the BCL-2 protein family localize at the outer mitochondrial membrane ...

Hyperphosphorylation of BCL-2 family proteins underlies functional ...

In particular, phosphorylation of antiapoptotic BCL-2 at serine 70 (S70pBCL-2) has been shown to promote cancer cell survival in response to ...

Bcl-2 family proteins in breast development and cancer - Oncotarget

In the context of breast cancers, Bcl-2 dysregulation promotes innate or acquired treatment resistance. This review will focus on the role of ...