EGF‑stimulated AKT activation is mediated by EGFR recycling via an ...

We suggest that EGF-stimulated recycling of EGFR to the plasma membrane induces downstream signaling leading to AKT phosphorylation.

EGF‑stimulated AKT activation is mediated by EGFR recycling via an early endocytic pathway in a gefitinib‑resistant human lung cancer cell line. Yukio Nishimura.

(PDF) EGF‑stimulated AKT activation is mediated by EGFR recycling ...

Using immunofluorescence, we observed an efficient endocytic transport of pEGFR from early endosomes to late endosomes/lysosomes after EGF‑stimulation in the ...

EGF-stimulated AKT activation is mediated by EGFR recycling via an ...

EGF-stimulated AKT activation is mediated by EGFR recycling via an early endocytic pathway in a gefitinib-resistant human lung cancer cell line · Fingerprint.

EGF receptor trafficking: consequences for signaling and cancer

Dimerization is crucial for ligand-stimulated EGFR autophosphorylation, activation, and internalization, with the exception of constitutively active mutant ...

Epidermal growth factor–stimulated Akt phosphorylation requires ...

Epidermal growth factor (EGF) binding to its receptor (EGFR) activates several signaling intermediates, including Akt, leading to control of cell survival and ...

Regulation of EGF-stimulated activation of the PI-3K/AKT pathway ...

Moreover, prolonged inhibition of EGF signaling by EGFR tyrosine kinase inhibitors results in spontaneous reactivation of AKT without a concomitant relief of ...

Regulation of EGF-stimulated activation of the PI-3K/AKT pathway ...

Moreover, prolonged inhibition of EGF signaling by EGFR tyrosine kinase inhibitors results in spontaneous reactivation of AKT without a ...

EGF-dependent re-routing of vesicular recycling switches ... - eLife

Autocatalytic activation of epidermal growth factor receptor (EGFR) coupled to dephosphorylating activity of protein tyrosine phosphatases ...

Fyn and TOM1L1 are recruited to clathrin-coated pits and regulate ...

EGF binding to EGFR elicits the membrane recruitment and activation of phosphatidylinositol-3-kinase, leading to Akt phosphorylation and ...

Ligand-activated epidermal growth factor receptor (EGFR) signaling ...

EGFR endocytosed via the non-canonical pathway is largely recycled back to the plasma membrane as functional receptors, whereas p38-independent populations are ...

Regulation of EGF-stimulated activation of the PI-3K/AKT ... - PNAS

Epidermal growth factor receptor (EGFR) signaling regulates many critical cellular processes, such as cell proliferation. The role of membrane trafficking ...

Activated EGFR and PDGFR internalize in separate vesicles and ...

EGFR phosphorylation and dimerization increases after cholesterol removal. ... EGF-dependent activation of downstream AKT and ERK1/2 is reduced upon cholesterol ...

AKT facilitates EGFR trafficking and degradation by phosphorylating ...

We showed that AKT facilitated the endocytic trafficking of EGFR to promote its degradation. Interfering with AKT signaling reduced both EGFR recycling and the ...

ISGylation drives basal breast tumour progression by promoting ...

EGF stimulation in the crISG15 and crUBC8 compared to the control (Fig. 3B). In addition, we observed higher peak and sustained Akt ...

AKT regulates EGFR recycling. Percent recycling was calculated in ...

AKT regulates EGFR recycling. Percent recycling was calculated in cells that were pretreated with AKTVIII for 20 min and stimulated with EGF or TGFa for 15 ...

Increased Expression of Epidermal Growth Factor Receptor Induces ...

EGFR activation stimulates the exchange of GTP for GDP on Ras leading to its activation (7). Ras is known to be a key component in mitogenic signaling in ...

Emerging functions of the EGFR in cancer - Sigismund - FEBS Press

The Epidermal Growth Factor Receptor (EGFR) regulates epithelial tissue development and is a driver of tumorigenesis.

ZNRF1 Mediates Epidermal Growth Factor Receptor Ubiquitination ...

Here, we reveal that ZNRF1, an E3 ubiquitin ligase, controls ligand-induced EGFR signaling via mediating receptor ubiquitination.

Epidermal Growth Factor Receptor Cell Proliferation Signaling ...

As these pathways are inter-linked, the activation of the EGFR actually stimulates an entire signaling network associated with a wide number of outcomes, such ...