- ER Ca2+ overload activates the IRE1α signaling and promotes cell ...🔍
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- ER Ca2+ overload activates the IRE1α signaling and ...🔍
- Additional file 4 of ER Ca2+ overload activates the IRE1α signaling ...🔍
- Additional file 3 of ER Ca2+ overload activates the IRE1α signaling ...🔍
- ER Stress|Mediated Signaling🔍
- Emerging roles for the ER stress sensor IRE1α in metabolic ...🔍
- Reduced IRE1α mediates apoptotic cell death by disrupting calcium ...🔍
ER Ca2 overload activates the IRE1α signaling and promotes cell ...
ER Ca2+ overload activates the IRE1α signaling and promotes cell ...
Results. Here, we report for the first time that overloading of ER Ca2+ can directly sensitize the IRE1α-XBP1 axis. The overloaded ER Ca2+ in ...
ER Ca2+ overload activates the IRE1α signaling and promotes cell ...
Our data establish a causal link between excess Ca 2+ in ER stores and the selective activation of IRE1α-XBP1 axis, underscoring an ...
(PDF) ER Ca2+ overload activates the IRE1α signaling and ...
PDF | Background: Maintaining homeostasis of Ca2+ stores in the endoplasmic reticulum (ER) is crucial for proper Ca2+ signaling and key cellular.
[PDF] ER Ca2+ overload activates the IRE1α signaling and ...
ER Ca2+ overload activates the IRE1α signaling and promotes cell survival · Song Zhao, Haiping Feng, +7 authors. T. Tang · Published in Cell & Bioscience 3 July ...
ER Ca2+ overload activates the IRE1α signaling and ...
ER Ca2+ overload activates the IRE1α signaling and promotes cell survival. ... ER Ca2+ overload. ER stress IRE1α. TMCO1. Abstract: Background ...
Additional file 4 of ER Ca2+ overload activates the IRE1α signaling ...
Additional file 4. TMCO1 KD activates IRE1α to prevent cell death. Related to Fig. 6. (a) qRT-PCR analysis of Xbp1s in the liver from 2-month-old WT mice ...
ER Ca2+ overload activates the IRE1α signaling and promotes cell ...
ER Ca2+ overload activates the IRE1α signaling and promotes cell survival. by Song Zhao, Haiping Feng, Dongfang Jiang, Keyan Yang, Si-Tong Wang, ...
ER Ca2+ overload activates the IRE1α signaling and ...
The overloaded ER Ca2+ in TMCO1-deficient cells can cause BiP dissociation from IRE1α, promote the dimerization and stability of the IRE1α protein, and boost ...
ER Ca2+ overload activates the IRE1α signaling and promotes cell ...
Abstract Background Maintaining homeostasis of Ca2+ stores in the endoplasmic reticulum (ER) is crucial for proper Ca2+ signaling and key cellular functions ...
Additional file 3 of ER Ca2+ overload activates the IRE1α signaling ...
Additional file 3 of ER Ca2+ overload activates the IRE1α signaling and promotes cell survival · Song Zhao · Haiping Feng · Dongfang Jiang · Keyan Yang · Si-Tong ...
ER Stress-Mediated Signaling: Action Potential and Ca2+ as Key ...
Prolonged UPR activation or adaptive response failure can promote a pro-survival response to a pro-apoptotic signaling, especially in the pathological condition ...
Emerging roles for the ER stress sensor IRE1α in metabolic ...
... activation and impaired insulin signaling in α-cells. It ... activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.
Reduced IRE1α mediates apoptotic cell death by disrupting calcium ...
... ER stress triggers cell death and Ca2+ dysregulation via the IRE1α-dependent signaling pathway. In this study, we show that inactivation of ...
Endoplasmic reticulum stress: molecular mechanism and ... - Nature
... IRE1α/XBP1 signaling and alleviating ER stress in the cells. It ... cells and activates autophagy via the PI3K/AKT/mTOR signaling pathway.
Role of Endoplasmic Reticulum Stress Sensor IRE1α in Cellular ...
IRE1α triggers cell death by promoting the ... Sigma-1 Receptor Chaperones at the ER- Mitochondrion Interface Regulate Ca2+ Signaling and Cell Survival.
Targeting endoplasmic reticulum stress signaling in ovarian cancer ...
... cell death in OC cells characterized by ERS activation ... enhances cisplatin sensitivity of ovarian cancer cells by increasing er ca2+ release.
ER stress-induced cell death mechanisms - ScienceDirect.com
Prolonged activation of RIDD signaling can promote cell death through a process shown to be dependent upon the conformational state of IRE1α. Mechanisms ...
The Structure, Activation and Signaling of IRE1 and Its Role ... - MDPI
Recently, it has been reported that PERK/ATF4 arm of the UPR may also induce the IRE1α/XBP1 pathway in ER-stressed cell, in addition to ATF6: ...
ER Ca2+ overload activates the IRE1[alpha] signaling and promotes ...
Maintaining homeostasis of Ca.sup.2+ stores in the endoplasmic reticulum (ER) is crucial for proper Ca.sup.2+ signaling and key cellular functions.
Activation of IRE1α as a metabolic stress sensor. In addition to...
In addition to protein folding overload within the ER lumen, the mammalian ER-localized transmembrane stress sensor IRE1α can also sense the indicated nutrient ...