ETV6|PDGFRB and FIP1L1|PDGFRA stimulate human ...

ETV6-PDGFRB and FIP1L1-PDGFRA stimulate human ...

ETV6-PDGFRB (also called TEL-PDGFRB) and FIP1L1-PDGFRA are receptor-tyrosine kinase fusion genes that cause chronic myeloid malignancies associated with ...

ETV6-PDGFRB and FIP1L1-PDGFRA stimulate human ...

Abstract ... (also called ) and are receptor-tyrosine kinase fusion genes that cause chronic myeloid malignancies associated with hypereosinophilia. The aim of ...

ETV6-PDGFRB and FIP1L1-PDGFRA stimulate human ... - PubMed

We show that human CD34(+) cells expressing PDGFR fusion oncogenes proliferate autonomously and differentiate towards the eosinophil lineage in a process that ...

Manuscript no. HAEMATOL/2011/047530 entitled “ETV6-PDGFRB ...

HAEMATOL/2011/047530 entitled “ETV6-PDGFRB and FIP1L1-. PDGFRA stimulate human hematopoietic progenitor proliferation and differentiation into eosinophils ...

(PDF) ETV6-PDGFRB and FIP1L1-PDGFRA stimulate human ...

PDF | ETV6-PDGFRB (also called TEL-PDGFRB) and FIP1L1-PDGFRA are receptor-tyrosine kinase fusion genes that cause chronic myeloid ...

ETV6-PDGFRB and FIP1l1-PDGFRA stimulate ... - DIAL@UCLouvain

To gain insight into the mechanisms whereby these fusion genes affect human hematopoietic cells and in particular the eosinophil lineage, we introduced ETV6- ...

Activation of FIP1L1-PDGFRα requires disruption of the ... - PNAS

... PDGFRA and the ETV6-WW-PDGFRB fusions observed in patients. Whereas in all ... activation of tyrosine kinases in human cancers (19, 24–27). This ...

Hematolymphoid Neoplasms Associated With Rearrangements of ...

ETV6-PDGFRB and FIP1L1-PDGFRA stimulate human hematopoietic progenitor cell proliferation and differentiation into eosinophils: the role of ...

A Tyrosine Kinase Created by Fusion of the PDGFRA and FIP1L1 ...

The clinical response to imatinib suggests that the hypereosinophilic syndrome may also be associated with constitutive activation of ABL, KIT, PDGFR, or an as ...

t(5;12)(q33;p13) ETV6/PDGFRB

ETV6-PDGFRB and FIP1L1-PDGFRA stimulate human hematopoietic progenitor cell proliferation and differentiation into eosinophils: the role of ...

New insights about the PDGF/PDGFR signaling pathway as a ...

Numerous cancers express platelet-derived growth factors (PDGFs) and PDGF receptors (PDGFRs). By directly stimulating tumour cells in an autocrine manner or ...

PDGFRB disease: right diagnosis to prolong survival

The absence of FIP1L1-PDGFRA indicates the need to promptly evaluate other recurrent abnormalities as PDGFRB or FGFR1 fusion genes. Molecular ...

Platelet-derived growth factor receptors (PDGFRs) fusion genes ...

The ubiquity of tyrosine kinases, especially, PDGFR and its fusion partners have stimulated interest in the development of therapeutic targets for gene fusions ...

The FIP1L1-PDGFRα fusion tyrosine kinase in hypereosinophilic ...

Eosinophilia is also a feature of acute and chronic hematologic malignancies with rearrangements involving transcription factor ETV6 (ETS translocation variant ...

Myeloid neoplasms associated with eosinophilia and rearrangement ...

... activation of PDGFRA and PDGFRB fusions. N, N ... In patients with PDGFRA variants other than FIP1L1–PDGFRA or rearrangements of PDGFRB ...

PDGF receptor mutations in human diseases - DIAL@UCLouvain

In contrast, mice harboring a mosaic deletion of PDGFRA or PDGFRB are marked by a significant increase in adipose tissue formation [117]. The mechanism that ...

PDGFRA gene: MedlinePlus Genetics

The signaling pathways stimulated by the PDGFRA protein control many ... Human Services National Institutes of Health. Last updated July ...

Use of multitarget tyrosine kinase inhibitors to attenuate platelet ...

Although the mechanism has not been fully elucidated, data suggest that suppression occurs by reduced PDGFR transcription. Aberrant activation of this pathway ...

PDGFRB - Wikipedia

PDGFRB ; Gene location (Human). Chromosome 5 (human). Chr. ; PDGFRB, CD140B, IBGC4, IMF1, JTK12, PDGFR, PDGFR-1, PDGFR1, KOGS, PENTT, platelet derived growth ...

Platelet-derived growth factors and their receptors in normal and ...

... ETV6-PDGFRB or FIP1L1-PDGFRA. Most patients are males and ... In addition, PDGF was shown to enhance the expansion of megakaryocyte progenitors from human ...