Effects of TM peptides on SCTR and AT1aR homodimerization. A )...

Download scientific diagram | Effects of TM peptides on SCTR and AT1aR homodimerization. A ) SCTR-Rlu- and SCTR-YFP-cotransfected cells were treated with ...

Transmembrane peptides as unique tools to demonstrate the in vivo ...

Results from A and B were confirmed by saturation studies. C) STM-IV was able to lower SCTR homooligomerization. Interestingly, AT1aR TM peptide ATM-4, but not ...

Effects of TM peptides on formation of SCTR-AT1aR ... - ResearchGate

Download scientific diagram | Effects of TM peptides on formation of SCTR-AT1aR heterocomplexes. A , B ) SCTR-Rlu- and AT1aR-YFP-cotransfected cells were ...

In vivo actions of SCTR/AT1aR heteromer in controlling Vp ...

Similarly, in current research, specific TM peptides were successfully used in studying the in vivo role of SCTR/AT1aR heteromer in central Vp ...

Role of SCTR/AT1aR heteromer in mediating ANGII-induced ...

In addition, the interactions of SCTR/AT1aR heteromer can be inhibited by transmembrane (TM) peptides corresponding to the second and fourth TM ...

In vivo actions of SCTR/AT1aR heteromer in controlling Vp ...

Effect of TM peptides on plasma Vp release upon ANGII/SCT pretreatment. A ... power of two: protein dimerization in biology. Trends Biochem. Sci. 29 ...

1 In vivo actions of SCTR/AT1aR heteromer in controlling Vp ...

... AT1aR (13). 335. More importantly, we have reported the in vivo effects of these TM peptides to prevent hyperosmolality-induced. 336 drinking. Similarly, in ...

Oligomerization of Family B GPCRs: Exploration in Inter ... - Frontiers

Although no effect was observed for SCTR homodimers (8), ligand binding can negatively affect dimer formation of VPAC1R/VPAC2R/PTHR1 homo/heterodimers (8, 9, 31) ...

Disrupting GPCR Complexes with Smart Drug-like Peptides - MDPI

In this context, synthetic peptides derived from TM domains stand out as powerful tools that can be predictably targeted to disrupt GPCR ...

Disrupting GPCR Complexes with Smart Drug-like Peptides

In this context, synthetic peptides derived from TM domains stand out as powerful tools that can be predictably targeted to disrupt GPCR oligomers, especially ...

THE ROLE OF SECRETIN RECEPTOR IN THE ... - HKU Scholars Hub

......................... 124. 3.6.7 Synthetic transmembrane (TM) peptides of AT1aR and SCTR are tools to study the. SCTR/AT1R complex in ZG cells ...

Transmembrane segment peptides can disrupt cholecystokinin ...

It is suggested that the lipid-exposed face of the CCK receptor TM VI most contributes to oligomerization and supports external contactDimerization of ...

Role of SCTR/AT1aR heteromer in mediating ANGII-induced ... - PLOS

Fig 2. SCTR potentiates ANGII-induced increase in [Ca2+]i. (A) [Ca2+] ...

Molecular interaction of mouse secretin and angiotensin II receptors ...

... (TM) domain regions 2 and 4 in SCTR, and TM1 and TM4 in AT1aR. Within which, combinational use of mutant TM peptides and SCTR chi- meras revealed the ...

Secretin, at the hub of water-salt homeostasis

between SCTR and AT1aR was abolished. These peptides had no effect on SCTR/SCTR or AT1aR/AT1aR interaction. When. ATM-1 peptide was injected ...

Design and Characterization of Superpotent Bivalent Ligands ...

(B) To test synthetic transmembrane peptide effects on OTR homodimerization ... Since receptors for these peptides (AT1aR, SCTR) are coexpressed ...

Signaling Modification by GPCR Heteromer and Its Implication on X ...

Here, we demonstrate the interaction between SCTR and AVPR2 to modulate cellular signaling in vitro. Interestingly, we show in this report that upon heteromer ...

Oligomerization of Family B GPCRs: Exploration in Inter-Family ...

... dimerization of family B SCTR with family A angiotensin II receptor type 1a (AT1aR) modulates the signaling properties of the receptors (14). In view of the ...

Role of SCTR/AT1aR heteromer in mediating ANGII-induced ...

Synthetic SCTR transmembrane (TM) peptides STM-II/-IV were able to alter [Ca2+]i in C57 mice, but not the mice with mutated STM-II/-IV (STM-IIm/IVm) peptides.

Angiotensin Receptors Heterodimerization and Trafficking - Frontiers

... effects, among others, of Ang II. The opposite arm, the depressor ... homodimerization has been reported in monocytes from patients ...