Effects of disease|modifying treatments discontinuation in patients ...

Effects of disease-modifying treatments discontinuation in patients ...

Approximately one in five patients with RRMS does not have treatment adherence during the first 5 years of treatment. Type of DMT, level of ...

Effects of disease-modifying treatments discontinuation in patients ...

Patients' most common reasons for leaving treatments and restarting them were exhaustion from the chronic therapeutic process and exacerbation of symptoms, ...

Impact of discontinuing disease-modifying therapies on health care ...

DMT discontinuation, defined as a treatment gap exceeding 90 days in days supply, was the independent variable. Patients who discontinued DMTs ...

Impact of discontinuing disease-modifying therapies on health care ...

This study revealed that DMT discontinuation was associated with higher health care services utilization among midlife patients with MS, especially relapse- ...

Disease-Modifying Therapy Discontinuation in Multiple Sclerosis

Depending on the DMT that has been discontinued, there is also the potential for patients to mount a more robust vaccine response; this could be of benefit ...

Safety of Discontinuing Disease-modifying Therapy in Aging MS ...

While several studies have suggested stopping DMT may be safe in patients over 55 years old with at least two years without active relapses, ...

Discontinuation of first-line disease-modifying therapy in relapse ...

Sixty-three patients (48.5%) showed MRI activity after DMT discontinuation, 40 patients (30.8%) experienced relapse(s), and 29 patients (22.3%) ...

Treatment Switching and Discontinuation Over 20 Years in the Big ...

Background: Although over a dozen disease modifying treatments (DMTs) are available for relapsing forms of multiple sclerosis (MS), treatment interruption, ...

Discontinuation of disease-modifying therapy in patients with ...

Thus, treatment patterns vary between clinicians. To understand current clinical practices and implications of stopping DMT in older MS patients ...

Discontinuation of Disease-modifying Treatments in Relapsing ...

Eighty-seven out of 294 patients (29.6%) discontinued treatment, most of them within the first three years; no differences were found between ...

Discontinuing disease-modifying multiple sclerosis therapies

despite similar relapse rates in those who continued and those who discontinued such treatment, the hazard of disability progression was increased for patients ...

Discontinuing Disease-Modifying Therapies in Multiple Sclerosis

As benefits of presently available DMTs wane with age, disease duration, and the change from a relapsing to progressive phenotype, side effects and risks ...

Discontinuation of disease-modifying therapy for patients with ...

When we performed subgroup analysis to compare the impact of DMT discontinuation between older (age > 45) and younger (age ≤ 45) patients, we ...

Evolution of Disease Modifying Therapy Benefits and Risks - Frontiers

Literature review noted that adverse events increase with aging, notably infections in patients with higher disability and longer DMT duration. Additionally, we ...

Comparing Stopping or Continuing Use of Disease Modifying ...

In this study, the research team looked at whether older patients who stopped taking DMTs had a higher risk of new relapses than patients who kept taking them.

Disease Modifying Therapy Discontinuation in Patients with Multiple ...

DMTs in MS have robust effects on inflammatory activity but less on disability. The immune system becomes less functional with age and it is ...

Long-term clinical outcomes in patients with multiple sclerosis who ...

... treatments for patients with a highly active disease presentation. ... Effects of early treatment with glatiramer acetate in patients with ...

Effects of Disease-Modifying Treatments discontinuation in patients ...

Request PDF | Effects of Disease-Modifying Treatments discontinuation in patients with Relapsing-Remitting Multiple Sclerosis: A 5 Year Prospective Cohort ...

Stopping Disease-modifying Therapies for Multiple Sclerosis

These side effects are serious and happen often. ... The AAN develops these summaries as educational tools for neurologists, patients, family members, caregivers, ...

Treatment Discontinuation and Disease Progression with Injectable ...

The primary reasons for treatment discontinuation reported by participants in the NARCOMS database were categorized into four groups: efficacy, ...