Effects of senescence on the tumour microenvironment and ...

Effects of senescence on the tumour microenvironment ... - PubMed

Cellular senescence is a state of durable cell arrest that has been identified both in vitro and in vivo. It is associated with profound changes in gene ...

The presence of senescence during the early stages of tumour development has a beneficial effect in inhibiting progression. This growth arrest ...

Cellular senescence and the tumour microenvironment - PMC

5A), and when the senescence‐inducing machinery in epithelial cells is disrupted, it can lead to the onset of cancer. Another important tumour prevention ...

Reshaping of the tumor microenvironment by cellular senescence

The SASP plays important roles in determining the physiological effects exerted by senescent cells. Senescence was first described more than 60 ...

Tumor microenvironment and cellular senescence

Accumulation of therapy-induced senescent stromal cells generates adverse effects, compromising the efficiency of cancer treatment per se, and is also ...

Senescence and cancer — role and therapeutic opportunities - Nature

Senescence has key implications not only for tumour development but also for responses to anticancer therapy. Indeed, in various preclinical ...

Cytokine-Induced Senescence in the Tumor Microenvironment and ...

Nevertheless, cellular senescence also leads to the secretion of the SASP, known to be pro-tumorigenic, as it regulates anti-tumor immune responses and enhances ...

Senescence and Immunoregulation in the Tumor Microenvironment

Importantly, many of these immunosuppressive impacts of senescent cells occurred in the absence of tumor cells, indicating that senescent stroma ...

The role of cellular senescence and SASP in tumour ... - FEBS Press

Cellular senescence functions as a tumour suppressive mechanism, inhibiting the proliferation of cancer-prone cells. In precancerous cells ...

Aging microenvironment and antitumor immunity for geriatric oncology

Infiltrative immune cells drive the elimination of senescent tumor cells and may also eliminate non-senescent cancer cells via a bystander ...

Senescent Stromal Cells in the Tumor Microenvironment - MDPI

These negative effects are tightly correlated to senescence-associated secretion phenotype (SASP). SASP is defined as a collective term for pro-inflammatory ...

Exploiting senescence for the treatment of cancer - Nature

Replicative cells also require defence mechanisms to reduce the impact of these persistent stresses on tissue degeneration and to restrict ...

Cellular senescence and SASP in tumor progression and ...

These effects are driven by a varied set of EV cargos, including proteins, nucleic acids, and lipids, which support the functional roles of EVs ...

Metabolic and senescence characteristics associated with the ...

Cellular senescence in immune and tumor cells impacts anti-tumor responses and therapy resistance. Targeting immune cell metabolism and inducing tumor cell ...

Prognostic significance of senescence-related tumor ... - Aging-US

The impact of the senescence related microenvironment on cancer prognosis and therapeutic response remains poorly understood. In this study, we investigated ...

Senescence Rewires Microenvironment Sensing to Facilitate ...

In cancer, senescence has been shown to mediate both beneficial and detrimental effects on tissue biology. On one hand, senescence provides a ...

Senescence and Aging: Does It Impact Cancer Immunotherapies?

How cellular senescence and aging, either by directly altering the immune system fitness or indirectly through the modification of the tumor environment, ...

(PDF) The role of cellular senescence and SASP in tumour ...

While senescence‐associated growth arrest can inhibit the proliferation of cancer‐prone cells, the altered secretory profile of senescent cells, ...

Cytokine-induced senescence in the tumor microenvironment and ...

Senescence can be achieved by tumor-associated antigen-specific T helper 1 cells, cytokines or antibodies targeting immune checkpoints. This concept differs ...

Cancer‑associated fibroblasts under therapy‑induced senescence in ...

Standard cancer treatment typically exacerbates the senescence‑associated secretory phenotype (SASP) of senescent cancer cells and nonmalignant ...