Effects of the Anti|Tumor Agents Trabectedin and Lurbinectedin on ...

Effects of the Anti-Tumor Agents Trabectedin and Lurbinectedin on ...

Trabectedin and lurbinectedin share the unique feature of being able to simultaneously kill cancer cells and to affect several features of the ...

Effects of the Anti-Tumor Agents Trabectedin and Lurbinectedin on ...

Trabectedin and lurbinectedin share the unique feature of being able to simultaneously kill cancer cells and to affect several features of the TME, most notably ...

Specific Effects of Trabectedin and Lurbinectedin on ... - PubMed

Results: Human macrophages exhibit at least two different profiles in response to these drugs. One-fourth of the blood donors assayed (164 ...

(PDF) Effects of the Anti-Tumor Agents Trabectedin and ...

Trabectedin and lurbinectedin share the unique feature of being able to simultaneously kill cancer cells and to affect several features of the TME, most notably ...

Trabectedin and lurbinectedin: Mechanisms of action, clinical impact ...

... trabectedin, lurbinectedin, tumor microenvironment, uterine sarcoma, ovarian cancer, endometrial cancer ... agent lurbinectedin 3.2 mg/m2 ...

Specific Effects of Trabectedin and Lurbinectedin - ProQuest

Trabectedin and lurbinectedin are two potent onco-therapeutic drugs for the treatment of advanced soft tissue sarcomas. Here we show that, in addition to cancer ...

Lurbinectedin reduces tumour-associated macrophages and the ...

Lurbinectedin is a novel anticancer agent currently undergoing late-stage (Phase II /III) clinical evaluation in platinum-resistant ovarian, ...

Trabectedin and Lurbinectedin Modulate the Interplay between ...

It has extensively been reported that these anti-tumour drugs impact the tumour microenvironment (TME), target human tumour-associated macrophages (hTAM) ...

Ascites interferes with the activity of lurbinectedin and trabectedin

Trabectedin and its analogue lurbinectedin are effective drugs used in the treatment of ovarian cancer. Since the presence of ascites is a ...

Trabectedin and Lurbinectedin Modulate the Interplay between ...

Effects of the Anti-Tumor Agents Trabectedin and Lurbinectedin on Immune Cells of the Tumor Microenvironment. Front. Oncol. 2022, 12, 851790 ...

Lurbinectedin - an overview | ScienceDirect Topics

As a single agent, lurbinectedin also revealed impressive efficacy in relapsed SCLC, particularly in patients with platinum-sensitive relapse with a response ...

Trabectedin and Lurbinectedin Extend Survival of Mice Bearing C26 ...

Trabectedin (ET743) and lurbinectedin (PM01183) limit the production of inflammatory cytokines that are elevated during cancer cachexia.

(PDF) Trabectedin and Lurbinectedin Modulate the Interplay ...

TRB is indicated for patients with relapsed ovarian cancer in combination with pegylated liposomal doxorubicin, as well as for advanced soft ...

Trabectedin mechanism of action: what's new? - Semantic Scholar

The opportunity to combine direct cytotoxic activity with a capacity to favorably modify the tumor microenvironment, using either single-agent or ...

Trabectedin, a drug acting on both cancer cells and the tumour ...

The results clearly indicated that the macrophage-targeted effect was sufficient to significantly reduce neoplastic growth, under conditions ...

Immunometabolic actions of trabectedin and lurbinectedin on ...

Effects of the Anti-Tumor Agents Trabectedin and. Lurbinectedin on Immune Cells of the Tumor Microenvironment. Front Oncol. 2022;12(March):1 ...

‪Cristina Belgiovine‬ - ‪Google Scholar‬

Effects of the anti-tumor agents trabectedin and lurbinectedin on immune cells of the tumor microenvironment. P Allavena, C Belgiovine, E Digifico, R ...

Lurbinectedin induces depletion of tumor-associated macrophages ...

This drug presents a dual pharmacological effect that contributes to its in vivo antitumor activity: (i) specific binding to. DNA minor grooves, inhibiting ...

Safety and Efficacy of the Combination Lurbinectedin plus ...

Lurbinectedin is related to trabectedin, an agent approved in Europe (second line or greater, adult patients with advanced STS) and in the ...

Specific Effects of Trabectedin and Lurbinectedin on Human ...

Results: Human macrophages exhibit at least two different profiles in response to these drugs. One-fourth of the blood donors assayed (164 individuals) were ...