Elevated Endoplasmic Reticulum Stress Response Contributes to ...

Our data suggests that an exaggerated ER stress response in aging adipose tissue contributes to age-associated inflammation that can be mitigated by treatment ...

Endoplasmic Reticulum Stress and Its Impact on Adipogenesis - NCBI

Elevated ER stress has the potential to stimulate inflammatory responses associated with adipocytes and insulin resistance [14]. This stimulation may lead to ...

Endoplasmic Reticulum Stress - an overview | ScienceDirect Topics

Endoplasmic reticulum stress ... Endoplasmic reticulum (ER) stress reflects functional overload of this organelle in response to increased protein synthesis or ...

Endoplasmic reticulum stress: molecular mechanism and ... - Nature

ER stress activates an adaptive unfolded protein response to restore proteostasis by initiating protein kinase R-like ER kinase, activating ...

The Emerging Roles of Endoplasmic Reticulum Stress in Balancing ...

The unfolded protein response (UPR) then ensues, which is one of the evolutionally conserved and protective mechanisms of the ER to resolve stress and ...

Endoplasmic Reticulum Stress - an overview | ScienceDirect Topics

Endoplasmic Reticulum Stress refers to a significant feature in prion diseases where complex pathways are activated in response to the stress caused by the ...

The aftermath of the interplay between the endoplasmic reticulum ...

The primary aim of the UPR is to restore cellular homeostasis; however, it triggers apoptotic signaling during prolonged stress. The core ...

Endoplasmic reticulum stress signalling – from basic mechanisms to ...

Specific ER stress signalling pathways, collectively known as the unfolded protein response (UPR), are required for maintaining ER homeostasis.

Endoplasmic Reticulum (ER) Stress Response Failure in Diseases

Its physiological perturbations affect its function, increase protein-folding demand, and accumulate unfolded/misfolded proteins inside the ER ...

Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

In this review, we address the transition from physiology to pathology, namely how and why the physiological UPR evolves to a proapoptotic ER stress response ...

Endoplasmic Reticulum Unfolded Protein Response, Aging and ...

Loss of protein folding regulation, which leads to unfolded or misfolded proteins accumulation inside the ER lumen, drives ER stress (ERS) and ...

The Endoplasmic Reticulum Stress Response in Neuroprogressive ...

ER stress and the subsequent activation of the UPR may lead to an increased production of ROS and subsequently to oxidative stress via a number ...

Translational control in the endoplasmic reticulum stress response

The upstream signal that activates these pathways is referred to as ER stress and is defined functionally as an imbalance between the load of client proteins ...

Endoplasmic reticulum stress contributes to beta cell apoptosis in ...

We demonstrated that the pro-apoptotic fatty acid palmitate triggers a comprehensive ER stress response in MIN6 cells, which was virtually ...

Endoplasmic reticulum stress and therapeutic strategies in ...

... leads to endoplasmic reticulum stress (ER stress). As ER stress ensues, the unfolded protein response (UPR), comprising three signaling ...

Unfolding the Interactions between Endoplasmic Reticulum Stress ...

To combat ER stress, cells initiate a highly conserved stress response called the unfolded protein response (UPR). While UPR signaling, within ...

Endoplasmic reticulum stress: a key player in human disease

Adequate respiration is necessary to generate the high levels of ATP consumed in all cells where ER protein folding takes place. In tissues with ...

Endoplasmic Reticulum Stress Regulator XBP-1 Contributes to ...

ER stress caused by the accumulation of unfolded proteins in the ER activates the unfolded protein response (UPR), a mechanism that restores ...

Impaired autophagy activity is linked to elevated ER-stress and ...

We speculated that elevated ER stress in aging adipose tissue may be due to defective protein turnover by proteasomes and/or lysosomes. Recent reports suggested ...

Role of endoplasmic reticulum stress in depression (Review)

Under ER stress, the unfolded protein response (UPR) is activated to minimize the overloading caused by the unfolded proteins. However, if ER ...