Elucidating the role of the A2A adenosine receptor in ...

Elucidating the role of the A2A adenosine receptor in ... - PubMed

We show that human iPSCs can be successfully induced to differentiate into DARPP32-positive, GABAergic neurons which express the A2AR in a similar manner to ...

We show that human iPSCs can be successfully induced to differentiate into DARPP32-positive, GABAergic neurons which express the A 2A R in a similar manner to ...

A2A adenosine receptors in human peripheral blood cells - PMC

Adenosine mediates a wide range of physiological functions by activation of at least four cell surface receptors named A1, A2A, A2B and A3. Each receptor ...

Elucidating Interactome Dynamics of the A2A Adenosine Receptor

Activation of ADORA2A leads to the activation of ADORA2A-interacting proteins with similar functions. To investigate the changes and dynamics of ...

Adenosine Receptor - an overview | ScienceDirect Topics

The critical role of adenosine A2A receptors in downregulation of inflammation and immunity in the pathogenesis of infectious diseases ... Adenosine receptors are ...

ddv318.pdf - Oxford Academic

Elucidating the role of the A2A adenosine receptor in neurodegeneration using neurons derived from. Huntington's disease iPSCs. Feng-Lan Chiu1 ...

How do adenosine A2A receptors regulate motor function?

Adenosine A2A antagonists act to normalize the activity of the indirect pathway in PD. Abstract. Adenosine A2A receptor antagonism is a new therapeutic strategy ...

Dual roles of the adenosine A2a receptor in autoimmune ...

A2aR activation exerts a complex pattern in chronic autoimmune neurodegeneration: while providing anti-inflammatory effects on T cells and thus protection at ...

A2A Adenosine Receptor: A Possible Therapeutic Target for ... - MDPI

The A2A adenosine receptor, a member of the P1 purinergic receptor family, plays a crucial role in the pathophysiology of different neurodegenerative ...

Adenosine A2A Receptor Antagonists in Neurodegenerative Diseases

For decades, adenosine receptors have shown promise as targets of medications for a variety of ailments. Until recently, however, the only approved medicine was ...

The caffeine-binding adenosine A2A receptor induces age-like HPA ...

In particular, activation of the adenosine A2A receptor (A2AR) was shown to contribute to the stress response by inducing corticosterone ...

Adenosine A2A receptor antagonists: from caffeine to selective non ...

Neuronal A2A receptor overexpression exacerbates memory and learning impairment and increases gene expression connected to microglial function.

Adenosine A1 and A2A Receptors in the Brain - MDPI

Adenosine signaling has been well studied in the brain and plays a complex role in multiple physiological and pathophysiological processes. · Of the four ...

A2AR eGFP reporter mouse enables elucidation of A2AR ... - Nature

There is significant clinical interest in targeting adenosine-mediated immunosuppression, with several small molecule inhibitors having been ...

Activation of the A2A adenosine G-protein-coupled receptor by ...

Insights into adenosine A2A receptor activation through cooperative modulation of agonist and allosteric lipid interactions · Chemistry, Medicine. PLoS Comput.

Adenosine research | Karolinska Institutet

Considerable effort is spent on elucidating the interactions between co expressed A2A and dopamine D2 receptors, because this interaction is a key to the ...

Elucidating Interactome Dynamics of the A2A Adenosine Receptor

We conducted gene ontology (GO) analysis and physical network analysis and discovered a novel network of proteins related to neuronal differentiation among the ...

Activation Microswitches in Adenosine Receptor A2A Function as ...

G states of A2AR but plays a different role in how they modulate the receptor activity and stability in each conformational state. PIP2 forms ...

Regulation of Platelet Function By Adenosine Receptors | Blood

Although studies have shown that stimulate A2a can inhibit platelet aggregation and elevate cAMP, there is little data elucidating the function ...

Elucidating the role of the A2A adenosine receptor in ...

題名: Elucidating the role of the A2A adenosine receptor in neurodegeneration using neurons derived from Huntington's disease iPSCs. 作者: Chiu, F-L