Emerging Role for Members of the Bcl|2 Family in Mitochondrial ...

Emerging role for members of the Bcl-2 family in mitochondrial ...

Bcl-2 family proteins regulate apoptosis by controlling the release of mitochondrial cytochrome c via the Bax/Bak channel. However, recent studies have also ...

Emerging Role for Members of the Bcl-2 Family in Mitochondrial ...

Members of the Bcl-2 protein family play pivotal roles in regu- lating caspase activation through regulating mitochondrial outer membrane permeability (MOMP).

Emerging Role for Members of the Bcl-2 Family in Mitochondrial ...

Members of the Bcl-2 protein family play pivotal roles in regulating caspase activation through regulating mitochondrial outer membrane permeability (MOMP).

Emerging Role for Members of the Bcl-2 Family in Mitochondrial ...

Bcl-2 family proteins regulate apoptosis by controlling the release of mitochondrial cytochrome c via the Bax/Bak channel. However, recent studies have also ...

New role of the BCL2 family of proteins in the regulation of ...

In mammals, over-expression of the pro-apoptotic BCL2 family member Bax promotes Drp1-dependent mitochondrial fragmentation [6]. Interestingly, during apoptosis ...

BCL-2 family proteins: changing partners in the dance towards death

The BCL-2 family of proteins controls cell death primarily by direct binding interactions that regulate mitochondrial outer membrane permeabilization (MOMP).

The role of BCL-2 family proteins in regulating apoptosis and cancer ...

Members of the B-cell lymphoma 2 (BCL-2) protein family have pro- or anti-apoptotic activities and have been studied intensively over the past decade for their ...

Emerging biomarkers and potential therapeutics of the BCL-2 ...

BCL-2 gene is found in intracellular membranes such as the endoplasmic reticulum and mitochondria, and other members of the family are ...

The role of the Bcl-2 family in the regulation of outer mitochondrial ...

Anti-apoptotic Bcl-2 family members have been shown to prevent the matrix swelling, ROS damage, release of cytochrome c and loss of membrane ...

New role of the BCL2 family of proteins in the regulation of ...

The role and regulation of these machineries are currently under intense investigation. Recently, members of the BCL2 family of proteins, conserved regulators ...

Balancing life and death: BCL‐2 family members at diverse ER ...

Although the BCL-2 family members are primarily thought of for their role in mediating mitochondrial outer membrane permeabilization (MOMP) by ...

Bcl-2 Family Proteins Participate in Mitochondrial Quality Control by ...

Here, we show that Parkin-dependent mitophagy is antagonized by prosurvival members of the Bcl-2 family (eg, Bcl-xL and Mcl-1) in a Beclin-1-independent manner.

Bcl-2 Family of Proteins in the Control of Mitochondrial Calcium ...

... mitochondrial pathway of apoptosis. However, in recent years Bcl-2 family members began to emerge as a new class of intracellular calcium (Ca2+) regulators ...

Control of mitochondrial apoptosis by the Bcl-2 family

In response to many types of stress or damage, certain members of the Bcl-2 family, known as BH3-only proteins (see below), are activated.

Role of Bcl‐2 family proteins in apoptosis: apoptosomes or ...

Bcl-2 and Bcl-xL are localized in the mitochondrial membrane as well as in the endoplasmic reticulum membrane and the nuclear envelope. Bcl-2 ...

New role of the BCL2 family of proteins in the regulation of ...

Bcl-2 is a vital member of the Bcl-2 gene family, which belongs to the anti apoptotic gene, encoding a mitochondrial membrane protein, located in the ...

[PDF] BCL-2 family members and the mitochondria in apoptosis.

... emerging subset of “BH3-domain-only” members who display sequence ... Bcl-2-family proteins and the role of mitochondria in apoptosis. T. KuwanaD ...

(PDF) Bcl-2 family interaction with the mitochondrial morphogenesis ...

Bcl-2 family proteins, central in apoptosis regulation, also have roles in the maintenance of the mitochondrial network. Here we report that Bax ...

Bcl-2 Family Members and the Mitochondrial Import Machineries

The role of TOM22 as the mitochondrial receptor for Bax during apoptosis has been a matter of debate. In glioblastoma cells and in isolated ...

Bcl-2 family proteins as regulators of cancer cell invasion and ...

While the mechanisms underlying these non-apoptotic functions of Bcl-2 proteins are still poorly understood, reactive oxygen species (ROS) have ...