Emerging roles of mitochondrial functions and epigenetic changes ...

Mitochondria serve as essential organelles that play a key role in regulating stem cell fate. Mitochondrial dysfunction and stem cell ...

(PDF) Emerging roles of mitochondrial functions and epigenetic ...

Mitochondrial dysfunction and stem cell exhaustion are two of the nine distinct hallmarks of aging. Emerging research suggests that epigenetic ...

Mitochondria serve as essential organelles that play a key role in regulating stem cell fate. Mitochondrial dysfunction and stem cell exhaustion are two of ...

Mitochondrial regulation of epigenetics and its role in human diseases

In particular, these studies demonstrate reversible or irreversible changes in genomic DNA methylation profiles of the nuclear genome. Here we review how ...

Epigenetic Control of Mitochondrial Function in the Vasculature

In the present review, we describe the emerging role of epigenetic modifications as fine tuners of gene transcription in mitochondrial dysfunction and vascular ...

Mitochondria and Epigenetics – Crosstalk in Homeostasis and Stress

We also discuss the emerging field of mitochondrial DNA (mtDNA) methylation, whose physiological role remains unknown. Finally, we describe the essential role ...

Mitoepigenetics and Its Emerging Roles in Cancer - Frontiers

Post-translational modifications of proteins in mitochondrial nucleoids such as mitochondrial transcription factor A (TFAM) also emerge as essential epigenetic ...

The emergent role of mitochondrial RNA modifications in metabolic ...

Each cell contains many mitochondria, and each mitochondrion contains many copies of its own DNA. The human mitochondrial genome is a compact ...

An Epigenetic Role of Mitochondria in Cancer - MDPI

Besides DNA methylation, mitochondrial metabolism also plays a pivotal role in the modifications of histone tails [143]. Chromatin structure and function are ...

Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic ...

The epigenetic modifications are crucial for DNA repair, cell cycle regulation, apoptosis and genomic instability. For instance, several DNA repair genes are ...

Mitochondrial-to-nuclear communication in aging: an epigenetic ...

Mito-nuclear communication plays an integral role in cellular homeostasis and aging. Mitochondrial metabolites are substrates or mediators of epigenetic ...

From evolutionary bystander to master manipulator - Nature

Recent findings may radically change our perception of mitochondria's capacity to have an impact on organismal fitness, revealing the presence ...

Mitochondrial regulation of epigenetics and its role in human diseases

We propose that “mitocheckpoint” mediated epigenetic and genetic changes may play key roles in phenotypic variation related to mitochondrial diseases or ...

Emerging roles of epigenetic regulation in obesity and metabolic ...

This review summarizes the current understanding of the pathophysiological roles of epigenetics, particularly focusing on DNA methylation in the ...

The epigenetic mechanisms involved in mitochondrial dysfunction ...

These factors cause numerous molecular changes such as oxidative stress, the release of neurotoxins, and epigenetic modifications, affecting ...

Emerging roles for Mitochondrial Rho GTPases in tumor biology

Mitochondrial Rho GTPases (MIRO1 and MIRO2) are primarily studied for their role as resident mitochondrial anchor proteins that facilitate mitochondria ...

Emerging roles of mitochondrial functions and epigenetic changes ...

Mitochondria serve as essential organelles that play a key role in regulating stem cell fate. Mitochondrial dysfunction and stem cell exhaustion ...

Regulation of mitochondrial gene expression, the epigenetic enigma.

The role of mtDNA methylation and potential epigenetic-like modifications of TFAM with respect to mtDNA transcription and replication are discussed and ...

Study discovers epigenetic regulator's critical role in mitochondrial ...

The intricate control of cellular metabolism relies on the coordinated and harmonious interplay between the nucleus and mitochondria.

Mitochondrial epigenetic modifications and nuclear-mitochondrial ...

The role of the mitochondria in modulating the nuclear epigenome is well known. S-adenosylmethionine (SAM), a universal methyl group donor, is ...