Emerging strategies for EphA2 receptor targeting for cancer ...

EphA2 has been tested as a drug target using multiple approaches such as agonist antibodies, RNA interference, immunotherapy, virus vector-mediated gene ...

This review describes EphA2 overexpression in cancers, its signaling mechanisms and strategies to target its deregulation.

Emerging strategies for EphA2 receptor targeting for cancer ...

What the reader will gain: High EphA2 expression in cancer cells is correlated with a poor prognosis associated with recurrence due to enhanced metastasis.

Emerging strategies for EphA2 receptor targeting for ... - Profiles RNS

Emerging strategies for EphA2 receptor targeting for cancer therapeutics. Expert Opin Ther Targets. 2011 Jan; 15(1):31-51. View in: PubMed. subject areas.

Emerging strategies for EphA2 receptor targeting for cancer ...

Over the years, many therapeutic strategies have been developed to target EphA2, including tyrosine kinase inhibitors, monoclonal antibodies, immunoconjugates, ...

Targeting EphA2 in cancer | Journal of Hematology & Oncology

Overall, EphA2 represents a potential target for treating malignant tumors. Introduction. Ephrin receptors (Eph) represent the most important ...

Emerging strategies for EphA2 receptor targeting for cancer ...

EphA2 overexpression in cancers, its signaling mechanisms and strategies to target its deregulation. High EphA2 expression in cancer cells is correlated with a ...

Emerging and Diverse Functions of the EphA2 Noncanonical ...

In contrast, ligand- and tyrosine kinase-independent EphA2 signaling (the noncanonical pathway) promotes tumor survival and metastasis and controls acquired ...

Emerging strategies for EphA2 receptor targeting for cancer ... - OUCI

Publications that cite this publication · EphA2- and HDAC-Targeted Combination Therapy in Endometrial Cancer · Targeted delivery of immune-stimulating bispecific ...

A Potent Agent Targeting the Ligand Binding Domain of EphA2

In phenotypic assays, the agents are also effective in suppressing cell migration in the BxPC3 pancreatic cancer cell line. When conjugated with ...

Unveiling the therapeutic promise of EphA2 in glioblastoma

Ephrin-A1-induced activation of EphA2 results in the inhibition of FAK, Akt, and ERK phosphorylation, which helps control cancer cell motility, ...

Therapy of pancreatic cancer via an EphA2 receptor-targeted ...

We show that the EphA2 receptor is highly expressed in pancreatic cancers, and accordingly, the drug-conjugate is more effective than ...

Cancer Gene Therapy Research - College of Veterinary Medicine

Cancer Gene Therapy Research ... The EphA2 receptor tyrosine kinase is frequently overexpressed in invasive breast cancer cells. Moreover, these malignant cells ...

EphA2 receptor tyrosine kinase as a promising target for cancer ...

Thus, EphA2 receptors are attractive targets for drug design, as targeting these molecules could simultaneously inhibit several aspects of tumor progression.

Independent Roles of EphA2 in the Regulation of Prostate Cancer ...

Ligand-activated Eph tyrosine kinases regulate cellular repulsion, morphology, adhesion, and motility. EphA2 kinase is frequently up-regulated in several ...

Targeted Delivery of Paclitaxel to EphA2-Expressing Cancer Cells

Experimental Design: By introducing non-natural amino acids, we have designed two new EphA2 targeting peptides: YNH, where norleucine and homoserine replace the ...

Full article: Related articles - Taylor & Francis

Emerging strategies for EphA2 receptor targeting for cancer therapeutics. Tandon M, Vemula SV, Mittal SK ; Enzalutamide for the treatment of ...

Cell adhesion and EGFR activation regulate EphA2 expression in ...

The results presented here bring new insight into the regulation of EphA2 expression in cancer cells and demonstrate an effective decrease in EphA2 expression ...

Targeting the EphA2 pathway: could it be the way for bone sarcomas?

The involvement of EphA2 in several solid tumors including melanoma, bone sarcomas, glioblastoma, lung, colorectal, prostate, pancreatic, ...

Targeting Ephrin Receptor Tyrosine Kinase A2 with a Selective ...

In this study, we demonstrate that their binding to cells is mediated by direct recognition of the ephrin type-A receptor 2 (EphA2).