Endoplasmic Reticulum Stress As a Therapeutic Target in ...

Endoplasmic reticulum stress as a therapeutic target in ... - PubMed

Therapeutic interventions that target molecules of the UPR component and reduce ER stress will be promising strategies to treat cardiovascular diseases.

In this review, we summarize the recent progress in understanding UPR signaling in cardiovascular disease and its related therapeutic potential.

Endoplasmic reticular stress as an emerging therapeutic target for ...

In the future, targeting ER stress to impact multiple molecular networks might be an attractive therapeutic strategy against chronic pain ...

Endoplasmic reticulum stress: molecular mechanism and ... - Nature

ER stress is involved in TM cell dysfunction and loss. Currently, there are chemicals, natural compounds, gene therapies, and stem cell ...

Endoplasmic reticular stress as an emerging therapeutic target for ...

We critically analyse preclinical studies and explore how ER stress can mechanistically act as a central node to drive development and progression of chronic ...

Review ER Stress: A Therapeutic Target in Rheumatoid Arthritis?

In rheumatoid arthritis (RA), inflammation and ER stress work in parallel by driving inflammatory cells to release cytokines that induce chronic ...

Endoplasmic Reticulum Stress: An Emerging Therapeutic Target for ...

This review will facilitate understanding the pathogenesis and progress of IDD and highlights potential therapeutic targets for treating this condition.

Therapeutic targeting of endoplasmic reticulum stress in acute graft ...

Inhibition of inositol-requiring enzyme 1α (IRE1α), the most conserved signaling branch in ER stress, reduced GvHD development in mice. IRE1α ...

Endoplasmic reticulum stress and therapeutic strategies in ...

As ER stress ensues, the unfolded protein response (UPR), comprising three signaling pathways—inositol-requiring enzyme 1, protein kinase R-like ...

Endoplasmic reticulum stress: a novel mechanism and ... - Nature

Endoplasmic reticulum stress (ERS) is a condition that is accelerated by the accumulation of unfolded/misfolded proteins after a disturbance in ...

Endoplasmic Reticulum Stress Signaling as a Therapeutic Target in ...

Malignant pleural mesothelioma (MPM) is a lethal cancer with limited treatment options. No targeted therapy has emerged yet.

Endoplasmic Reticulum Stress, a Target for Drug Design ... - Frontiers

In this review, we aim to clarify the role of ER stress pathways and related molecules in parasites for their survival and development.

Review ER Stress: A Therapeutic Target in Rheumatoid Arthritis?

In rheumatoid arthritis (RA), inflammation and ER stress work in parallel by driving inflammatory cells to release cytokines that induce chronic ER stress ...

Endoplasmic Reticulum Stress as a Novel Therapeutic Target in ...

The UPR aims at restoring cellular homeostasis, however, prolonged ER stress can trigger apoptosis. ER stress-induced apoptosis has been implicated in the ...

Pak2 as a Novel Therapeutic Target for Cardioprotective ...

The UPR serves to relieve ER stress by halting protein translation, increasing chaperone expression for refolding, and degrading irreparably ...

Endoplasmic Reticulum Stress and Emerging Therapeutic Targets in ...

This chapter highlights the current understanding of the signaling pathways of ER stress, the role of the UPR pathway in cancer development, and the relevant ...

Endoplasmic Reticulum Stress as a Therapeutic Target in Cancer

The role of UPR and its mediators in cancerous cells fate is highlighted and their potential opportunities in cancer therapy are discussed.

[PDF] Endoplasmic reticulum stress as a therapeutic target in ...

432 Citations · Endoplasmic reticulum stress and Nrf2 signaling in cardiovascular diseases. · The Role of Endoplasmic Reticulum Stress in Cardiovascular Disease ...

Targeting endoplasmic reticulum stress signaling in ovarian cancer ...

Hypoxia, nutrient deficiency, and a low pH tumor microenvironment lead to the accumulation of misfolded or unfolded proteins in the ER, thus ...

Targeting Endoplasmic Reticulum Stress as an Effective Treatment ...

ER stress results from the accumulation of unfolded/misfolded protein in the ER and is implicated in the pathogenesis of alcoholic pancreatitis. Here, we ...