Endoplasmic Reticulum and the Unfolded Protein Response

The endoplasmic reticulum and the unfolded protein response

The endoplasmic reticulum (ER) is the site where proteins enter the secretory pathway. Proteins are translocated into the ER lumen in an unfolded state and ...

The unfolded protein response: controlling cell fate decisions under ...

The unfolded protein response (UPR) buffers protein-folding stress at the endoplasmic reticulum (ER). Research has provided insight into the ...

Endoplasmic Reticulum and the Unfolded Protein Response

The best-known effect of UPR on cellular metabolism is the attenuation of general protein translation via eIF2α phosphorylation. Such negative regulation not ...

Signal integration in the endoplasmic reticulum unfolded protein ...

The endoplasmic reticulum (ER) responds to the accumulation of unfolded proteins in its lumen (ER stress) by activating intracellular signal transduction ...

Endoplasmic Reticulum and the Unfolded Protein Response

Most studies suggest that the tubular ER has the ability to fuse, elongate and branch dynamically inside the cell. Lower panel: The ER fulfills diverse ...

Endoplasmic Reticulum Stress, Unfolded Protein Response, and ...

In this review, we discuss the role played by the UPR program in tumor initiation, progression and resistance to therapy.

Unfolded protein response - Wikipedia

The unfolded protein response (UPR) is a cellular stress response related to the endoplasmic reticulum (ER) stress.

Endoplasmic reticulum: Monitoring and maintaining protein and ...

The Unfolded Protein Response (UPR) senses misfolded proteins and perturbations to lipid membrane homeostasis in the ER and initiates adaptive signaling ...

Endoplasmic Reticulum Unfolded Protein Response, Aging and ...

This article reviews the effects of aging and exercise on ERS and UPR, also analyzing possible changes induced by different types of exercise in elderly ...

The unfolded protein response and endoplasmic reticulum ... - eLife

The coordination of protein targeting to the endoplasmic reticulum and the unfolded protein response through the stress sensor IRE1 ensures ...

Membrane lipid saturation activates endoplasmic reticulum unfolded ...

However, it is unclear if direct sensing of the lipid perturbation contributes to UPR activation. We found that mutant mammalian ER stress ...

What is the Unfolded Protein Response? - YouTube

process is called the unfolded protein response, and it helps cells deal with problematic proteins ... ER protein folding? Animated biology With ...

Methods for Monitoring Endoplasmic Reticulum Stress and the ...

The UPR can promote cellular repair and sustained survival by reducing the load of unfolded proteins through upregulation of chaperones and ...

On the mechanism of sensing unfolded protein in the endoplasmic ...

Unfolded proteins in the endoplasmic reticulum (ER) activate the ER transmembrane sensor Ire1 to trigger the unfolded protein response (UPR), a homeostatic ...

Decay of Endoplasmic Reticulum-Localized mRNAs During the ...

The unfolded protein response (UPR) allows the endoplasmic reticulum (ER) to recover from the accumulation of misfolded proteins, in part by ...

Unfolded Protein Response (UPR) Pathway and ER Stress FAQs

The unfolded protein response (UPR) is a signaling mechanism activated in eukaryotic cells in response to endoplasmic reticulum/ER stress, an accumulation of ...

homeostasis, cell death and evolution in virus infections | FEMS ...

Viruses restore homeostasis by harnessing evolutionary conserved stress responses, such as the endoplasmic reticulum (ER) unfolded protein ...

Deciphering ER stress-unfolded protein response relationship by ...

We report a strategy of visualizing unfolded protein accumulation in the ER lumen in living cells by employing an engineered ER stress sensor, PERK.

Autophagy Counterbalances Endoplasmic Reticulum Expansion ...

The protein folding capacity of the endoplasmic reticulum (ER) is regulated by the unfolded protein response (UPR). The UPR senses unfolded proteins in the ...

QuickGO::Term GO:0030968

The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; ...