Endothelial Adora2a Activation Promotes Blood

Endothelial Adora2a Activation Promotes Blood–Brain Barrier ...

Endothelial Adora2a Activation Promotes Blood-Brain Barrier ...

These findings indicate that Adora2a-mediated signaling in vascular endothelial cells disrupts the BBB in dietary obesity, and implicate ...

Endothelial Adora2a Activation Promotes Blood–Brain Barrier ...

Endothelial Adora2a increases BBB permeability and promotes pericyte regression in diabetic mice. To investigate resistance to BBB leakiness in ...

Endothelial Adora2a activation promotes blood-brain barrier ...

Endothelial Adora2a activation promotes blood-brain barrier breakdown and cognitive impairment in mice with diet-induced insulin resistance. Masaki Yamamoto ...

Endothelial Adora2a Activation Promotes Blood–Brain Barrier ...

Obesity and insulin resistance elicit blood-brain barrier (BBB) breakdown in humans and animal models, but the relative contributions of the two pathologies ...

Adenosine A2A Receptor Activation Enhances Blood–Tumor Barrier ...

We then analyzed the downstream impact of A2AR agonism by regadenoson, on brain endothelial cell integrity, by knocking down Adora1 and/or Adora2a. After 30 ...

[PDF] Endothelial Adora2a Activation Promotes Blood–Brain Barrier ...

Endothelial Adora2a Activation Promotes Blood–Brain Barrier Breakdown and Cognitive Impairment in Mice with Diet-Induced Insulin Resistance · Masaki Yamamoto, De ...

New insight into how obesity, insulin resistance can impair cognition

Endothelial Adora2a activation promotes blood-brain barrier breakdown and cognitive impairment in mice with diet-induced insulin resistance.

Obesity-induced blood-brain barrier dysfunction: phenotypes and ...

Endothelial Adora2a activation promotes blood-brain barrier breakdown and cognitive impairment in mice with Diet-Induced insulin resistance.

Adenosine and adenosine receptors in metabolic imbalance-related ...

Endothelial Adora2a activation promotes blood-brain barrier breakdown and cognitive impairment in mice with diet-induced insulin resistance. J. Neurosci., 39 ...

GLP-1 programs the neurovascular landscape: Cell Metabolism

76. Yamamoto, M. ∙ Guo, D.H. ∙ Hernandez, C.M. ... Endothelial Adora2a Activation Promotes Blood-Brain Barrier Breakdown and Cognitive ...

The blood–brain barrier in health and disease: Important ...

G.R.. John . 2009 . VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier ... A.M.. Stranahan . 2019 . Endothelial Adora2a ...

Blood-brain barrier disruption: a culprit of cognitive decline?

Endothelial Adora2a activation promotes blood-brain barrier breakdown and cognitive impairment in mice with Diet-Induced insulin resistance.

Inducible ablation of Adora2a on endothelial cells maintains BBB...

Inducible ablation of endothelial Adora2a prevents high-fat... Endothelial Adora2a Activation Promotes Blood–Brain Barrier Breakdown and Cognitive Impairment in ...

Endothelial adenosine A2a receptor-mediated glycolysis is essential ...

Mechanistically, ADORA2A activation promotes the transcriptional induction of glycolytic enzymes via ERK- and Akt-dependent translational ...

Glial and Vascular Cell Regulation of the Blood-Brain Barrier in ...

Endothelial Adora2a activation promotes blood-brain barrier breakdown and cognitive impairment in mice with diet-induced insulin resistance. J Neurosci 2019 ...

A2A adenosine receptor modulates drug efflux transporter P ... - JCI

... brain endothelial cells upon activation ... P-glycoprotein in blood–brain barrier endothelial cells: interaction and oligomerization with ...

Purinergic signaling: A gatekeeper of blood-brain barrier permeation

Activation of RhoA in endothelial cells promotes the onset of BBB barrier ... Endothelial Adora2a activation promotes blood-brain barrier breakdown and ...

Inactivation of endothelial adenosine A2A receptors protects mice ...

... blood–brain barrier (BBB) leakage, and oedema assessment. Anti ... 3.1 Cerebral ischaemic injury increases expression of Adora2a in brain.

Inducible ablation of endothelial Adora2a prevents high-fat...

Inducible ablation of endothelial Adora2a prevents high-fat... Endothelial Adora2a Activation Promotes Blood–Brain Barrier Breakdown and Cognitive Impairment in ...

Inactivation of endothelial adenosine A2A receptors protects mice ...

These inflammatory reactions are preceded by disruption of the blood–brain barrier ... Cerebral ischaemic injury increases expression of Adora2a in brain.