Endothelial Adora2a activation promotes blood|brain barrier ...

Endothelial Adora2a Activation Promotes Blood-Brain Barrier ...

These findings indicate that Adora2a-mediated signaling in vascular endothelial cells disrupts the BBB in dietary obesity, and implicate ...

Endothelial Adora2a Activation Promotes Blood–Brain Barrier ...

Endothelial Adora2a increases BBB permeability and promotes pericyte regression in diabetic mice. To investigate resistance to BBB leakiness in ...

Endothelial Adora2a activation promotes blood-brain barrier ...

Endothelial Adora2a activation promotes blood-brain barrier breakdown and cognitive impairment in mice with diet-induced insulin resistance. Masaki Yamamoto ...

Endothelial Adora2a Activation Promotes Blood–Brain Barrier ...

Obesity and insulin resistance elicit blood-brain barrier (BBB) breakdown in humans and animal models, but the relative contributions of the two pathologies ...

[PDF] Endothelial Adora2a Activation Promotes Blood–Brain Barrier ...

Endothelial Adora2a Activation Promotes Blood–Brain Barrier Breakdown and Cognitive Impairment in Mice with Diet-Induced Insulin Resistance · Masaki Yamamoto, De ...

Adenosine A2A Receptor Activation Enhances Blood–Tumor Barrier ...

... brain endothelial cell integrity, by knocking down Adora1 and/or Adora2a. After 30 minutes of regadenoson exposure, we observed ...

Obesity-induced blood-brain barrier dysfunction - PubMed Central

Endothelial Adora2a activation promotes blood-brain barrier breakdown and cognitive impairment in mice with Diet-Induced insulin resistance.

New insight into how obesity, insulin resistance can impair cognition

Endothelial Adora2a activation promotes blood-brain barrier breakdown and cognitive impairment in mice with diet-induced insulin resistance.

Adenosine and adenosine receptors in metabolic imbalance-related ...

Endothelial Adora2a activation promotes blood-brain barrier breakdown and cognitive impairment in mice with diet-induced insulin resistance. J. Neurosci., 39 ...

Purinergic signaling: A gatekeeper of blood-brain barrier permeation

Activation of RhoA in endothelial cells promotes the onset of BBB barrier ... Endothelial Adora2a activation promotes blood-brain barrier breakdown and ...

The blood–brain barrier in health and disease: Important ...

G.R.. John . 2009 . VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier ... A.M.. Stranahan . 2019 . Endothelial Adora2a ...

Inactivation of endothelial adenosine A2A receptors protects mice ...

... blood–brain barrier (BBB) leakage, and oedema assessment. Anti ... 3.1 Cerebral ischaemic injury increases expression of Adora2a in brain.

GLP-1 programs the neurovascular landscape: Cell Metabolism

76. Yamamoto, M. ∙ Guo, D.H. ∙ Hernandez, C.M. ... Endothelial Adora2a Activation Promotes Blood-Brain Barrier Breakdown and Cognitive ...

Inducible ablation of Adora2a on endothelial cells maintains BBB...

Inducible ablation of endothelial Adora2a prevents high-fat... Endothelial Adora2a Activation Promotes Blood–Brain Barrier Breakdown and Cognitive Impairment in ...

Blockade of endothelial adenosine receptor 2 A suppresses ...

Mechanistically, ADORA2A upregulated ALK5 expression via a cAMP/PKA/CREB axis, leading to TGFβ-Smad2/3 signaling activation, thereby promoting EndMT. In ...

Endothelial adenosine A2a receptor-mediated glycolysis is essential ...

Mechanistically, ADORA2A activation promotes the transcriptional induction of glycolytic enzymes via ERK- and Akt-dependent translational ...

A2A adenosine receptor modulates drug efflux transporter P ... - JCI

The specialized endothelial cells of the blood-brain barrier (BBB) protect the brain from toxic substances, while allowing oxygen and other ...

Glial and Vascular Cell Regulation of the Blood-Brain Barrier in ...

Endothelial Adora2a activation promotes blood-brain barrier breakdown and cognitive impairment in mice with diet-induced insulin resistance. J Neurosci 2019 ...

Inducible ablation of endothelial Adora2a prevents high-fat...

Inducible ablation of endothelial Adora2a prevents high-fat... Endothelial Adora2a Activation Promotes Blood–Brain Barrier Breakdown and Cognitive Impairment in ...

Inactivation of endothelial adenosine A2A receptors protects mice ...

These inflammatory reactions are preceded by disruption of the blood–brain barrier ... Cerebral ischaemic injury increases expression of Adora2a in brain.