Endothelial Senescence

Mechanisms and consequences of endothelial cell senescence

We now understand that senescent endothelial cells are highly active, secretory and pro-inflammatory, and have an aberrant morphological phenotype.

Endothelial senescence in vascular diseases - Nature

Senescence compromises the essential role that the endothelium plays in maintaining vascular homeostasis, so promoting endothelial ...

Mechanisms and consequences of endothelial cell senescence - PMC

Senescent endothelial cells are highly active, secretory and pro-inflammatory, and exhibit an aberrant morphological phenotype.

The aging endothelium - PMC - PubMed Central

Cellular senescence is now recognized as one of the hallmarks of aging. Herein, we examine current findings on senescence of the vascular endothelium and ...

Endothelial cell senescence in aging-related vascular dysfunction

The senescence of vascular endothelial cells (ECs) has been found to play a key role in vascular aging leading to the initiation, progress, and advancement of ...

Endothelial Senescence: From Macro- to Micro-Vasculature and Its ...

Endothelial cells become senescent, characterized by reduced regeneration capacity, inflammation, and abnormal secretory profile.

Vascular Endothelial Senescence: Pathobiological Insights ...

We focus on pathobiological insights underlying cellular senescence of the vascular endothelium, a critical interface between blood and all tissues.

Endothelial aging | Cardiovascular Research - Oxford Academic

Aging is considered to be the major risk factor for the development of atherosclerosis and, therefore, for coronary artery disease.

Endothelial Senescence Contributes to Heart Failure With ...

Conclusions—. SAM develop endothelial dysfunction. Adding a high-salt, high-fat diet accelerates endothelial senescence and instigates ...

Mechanical Fingerprint of Senescence in Endothelial Cells

Senescent endothelial cells display a multifold increase in the levels of basal adhesion and force generation supported by mature and strong focal adhesions.

Resolvin E1 attenuates doxorubicin-induced endothelial ...

Senescent cells acquire a pro-inflammatory secretory phenotype that further propagates inflammation and senescence to neighboring cells. Cell senescence can be ...

Disturbed Flow Promotes Endothelial Senescence via a p53 ...

Disturbed flow promotes endothelial senescence via a p53-p21–dependent pathway which can be inhibited by activation of sirtuin 1. These ...

Endothelial cellular senescence is inhibited by nitric oxide - PNAS

The ingestion of NO-boosting substances, including l-arginine, l-citrulline, and antioxidants, can delay endothelial senescence under high glucose. We suggest ...

Endothelial Senescence and the Chronic Vascular Diseases - MDPI

Underlying the physiopathology of atherosclerosis are cellular senescence, oxidative stress, and inflammation. These factors are increased in the elderly and ...

Vascular endothelial senescence: from mechanisms to ...

Endothelial cell senescence can be induced by a number of factors implicated in vascular pathologies, particularly by sustained cell replication and oxidative ...

Senescence of endothelial cells promotes phenotypic changes in ...

Senescent cells release plethora of factors commonly known as the senescence-associated secretory phenotype, which can modulate the normal ...

Endothelial Senescence in Neurological Diseases

Abstract. Endothelial cells, which are highly dynamic cells essential to the vascular network, play an indispensable role in maintaining the normal function of ...

A new gene signature for endothelial senescence identifies self ...

We showed that endothelial cell senescence hallmarks include self-RNA accumulation, RNA sensor RIG-I upregulation, and an ISG signature.

Endothelial cell senescence with aging in healthy humans

Our study provides novel evidence in humans of increased endothelial cell senescence with sedentary aging, which is associated with impaired vascular ...

Elimination of Senescent Endothelial Cells: Good or Bad Idea?

Recent studies highlight the beneficial and adverse effects that eliminating senescent endothelial cells can have on health span, questioning ...