Engineered exosomes delivering specific tumor|suppressive RNAi ...

Engineered exosomes delivering specific tumor-suppressive RNAi ...

Exosomes are involved in a wide range of biological processes in human cells. Considerable evidence suggests that engineered exosomes ...

(PDF) Engineered exosomes delivering specific tumor-suppressive ...

Exosomes are involved in a wide range of biological processes in human cells. Considerable evidence suggests that engineered exosomes (eExosomes) containing ...

Engineered exosomes from different sources for cancer-targeted ...

The exosomes decorated with specific targeted molecules, including peptides, can achieve more precise therapeutic cargo delivery. The miR-HER2 ( ...

Targeted delivery of RNAi to cancer cells using RNA-ligand ...

Exosomes can be engineered to express a cell-surface-specific ligand that can be used to achieve targeted delivery to cancer cells. In order to reprogram ...

Exosome-mediated delivery of siRNA molecules in cancer therapy

These exosomes, with their unique characteristics and potential for effective siRNA delivery, represent a significant advancement in nanomedicine and cancer ...

Engineered exosomes for cancer theranostics: Next-generation ...

Moreover, pulsed DC-derived exosomes could prime nave T cells and activate NK cells to attack tumor cells [73]. Therefore, exosomes released by DCs have been ...

Engineered exosomes as drug and RNA co-delivery system - Frontiers

In general, tumor cells can release exosomes to influence the immune system, suggesting that tumor derived exosomes may also serve as vaccines for cancer ...

Tumor-targeted exosomes for delivery of anticancer drugs

Engineering exosomes with2019 cell-specific moieties enables tumor-targeted delivery of anticancer therapeutics. Abstract. Exosomes are small ...

Patient-Derived Exosomes as siRNA Carriers in Ovarian Cancer ...

We demonstrated that small interfering RNA replacement therapy using engineered exosomes exhibits promising effects in treating the peritoneal dissemination of ...

Engineered exosomes loaded with miR-449a selectively inhibit the ...

As an efficient drug carrier, exosome has been widely used in the delivery of genetic drugs, chemotherapeutic drugs, and anti-inflammatory ...

Engineered exosomes delivering specific tumor - OPAC

In murine pancreatic cancer cells, exosomes carrying a specific siRNA. 39. Page 4. 3 have been functionally modified to target oncogenic KRAS9, suggesting that ...

Preparation of Exosomes for siRNA Delivery to Cancer Cells - JoVE

An exosome is a new generation of drug delivery carriers. We established an exosome isolation protocol with high yield and purity for siRNA ...

Recent advances in exosome-mediated nucleic acid delivery for ...

Cancer cell-derived exosomes have a tropism toward cell origin due to their abundant biological components similar to their parent tumor cells, ...

Engineering exosomes for targeted drug delivery - Theranostics

These targeted exosomes delivered siRNA and miRNA to the corresponding tumor sites and enhanced antitumor efficacy. Another study explored the potential of chol ...

Exosome-Based Carrier for RNA Delivery: Progress and Challenges

So far, exosome-mediated RNA therapy has shown potential in the treatment of cancer, central nervous system disorders, COVID-19, and other diseases. To further ...

Engineered exosome-mediated delivery of functionally active miR ...

Small RNAs, including siRNA and miRNA, can be used as molecular therapeutics to treat a variety of diseases, including cancer, cardiac disease, ...

Harnessing exosomes as a platform for drug delivery in breast cancer

... exosomes with surface molecules for specific therapeutic agent delivery to cancer cells. ... packaged survivin siRNA within the modified exosomes ...

Exosomes: natural nanoparticles as bio shuttles for RNAi delivery

... Exosomes, as natural carriers, are often used as drug delivery vehicles to transport siRNA to target tissues or cells and inhibit tumor development [55][56] ...

Exosomes for siRNA Delivery - Subcellomics - Creative Proteomics

As a promising tool for nucleic acid drug delivery across different biological barriers, exosomes have been widely used to deliver siRNA. The capability of ...

A targeted siRNA‐loaded PDL1‐exosome and functional evaluation ...

In conclusion, exogenous siRNA can be loaded and delivered into target cells using targeted exosomes. Selective gene silencing can inhibit tumor ...