Epidermal growth factor–stimulated Akt phosphorylation requires ...

Upon ligand binding, the epidermal growth factor receptor (EGFR) activates signaling and undergoes endocytosis. EGFR signaling leading to Akt activation is ...

Epidermal growth factor-stimulated Akt phosphorylation requires ...

Epidermal growth factor (EGF) binding to its receptor (EGFR) activates several signaling intermediates, including Akt, leading to control of ...

Abstract · Selective regulation of clathrin-mediated epidermal growth factor receptor signaling and endocytosis by phospholipase C and calcium.

Epidermal growth factor–stimulated Akt phosphorylation requires ...

Epidermal growth factor–stimulated Akt phosphorylation requires clathrin or ErbB2 but not receptor endocytosis · 78 Citations · 82 References.

We have recently shown that phosphorylation of Gab1 and Akt following EGFR activation requires clathrin, but does not require receptor endocytosis. We examined ...

Epidermal Growth Factor Protects Epithelial Cells against Fas ...

Increased phosphorylation of Akt was detected within 5 min after EGF stimulation (Fig. 2 B). Twenty-four h after Fas ligation, Akt was still activated in EGF- ...

EGF‑stimulated AKT activation is mediated by EGFR recycling via an ...

In contrast, however, monensin had no effect on AKT phosphorylation triggered by activation of the MET receptor tyrosine kinase. Collectively, ...

Regulation of EGF-stimulated activation of the PI-3K/AKT pathway ...

The results presented in Fig. 4B show that Es2 completely inhibited AKT phosphorylation in a dose-dependent manner with an IC50 of 60.7 ± 6.1 µM (n = 4) ...

Inhibition of Src Family Kinases Blocks Epidermal Growth Factor (EGF)

We demonstrate that EGF stimulation of T47D cells results in the activation of the Src protein-tyrosine kinase and that the Src kinase inhibitor PP1 blocks the ...

Akt Binds to and Phosphorylates Phospholipase C-γ1 in Response ...

EGF induced the tyrosine phosphorylation of PLC-γ1 that releases the restriction of SH3 domain. Indeed, the two major phosphorylated tyrosine residues of PLC-γ1 ...

Platelet-derived growth factor-induced Akt phosphorylation requires ...

This reduction in Akt phosphorylation did not influence the phosphorylation of the S6 protein, a well established protein downstream of mTORC1.

Fyn and TOM1L1 are recruited to clathrin-coated pits and regulate ...

EGF binding to EGFR elicits the membrane recruitment and activation of phosphatidylinositol-3-kinase, leading to Akt phosphorylation and ...

Epidermal Growth Factor Receptor Cell Proliferation Signaling ...

As these pathways are inter-linked, the activation of the EGFR actually stimulates an entire signaling network associated with a wide number of outcomes, such ...

Epidermal Growth Factor Receptor-dependent Akt Activation by ...

Akt activation by H2O2 also depended on epidermal growth factor receptor (EGFR) signaling; H2O2 treatment led to EGFR phosphorylation, and inhibition of EGFR ...

Akt/Protein Kinase B Isoforms Are Differentially Regulated by ...

Upon EGF simulation, phosphorylation of Akt1 at the Ser-473 residue was remarkably induced. This result was corroborated by in vitro Akt kinase assays using ...

Dorsal ruffles enhance activation of Akt by growth factors

EGF stimulated lower maximal levels of pAkt than did PDGF, which suggests that Akt phosphorylation requires amplification in CDRs only when PI3K activities are ...

EGF-activated PI3K/Akt signalling coordinates leucine uptake by ...

Binding of EGF to EGFR stimulates downstream signalling pathways including the mitogen-activated protein kinase (MAPK) and phosphoinositide 3 ...

Protein Kinase C ζ Is Required for Epidermal Growth Factor ...

In this study, we showed that epidermal growth factor (EGF) was a more potent chemoattractant than chemokine SDF-1α/CXCL12 for human breast cancer cell MDA-MB- ...

H2O2-induced transactivation of EGF receptor requires Src and ...

The Src inhibitor PP1 completely blocked EGFR, ERK1/2, and Akt phosphorylation following H2O2 exposure. In contrast, blockade of the EGFR by AG1478 inhibited ...

Angiotensin II-induced growth of vascular smooth muscle cells ...

Figure 5 Ang II induces Shc tyrosine phosphorylation. (A) Quiescent VSMCs were stimulated with Ang II (100 nmol/L) or EGF (10 ng/mL) for five minutes. Prior to ...