Epigenetic Regulation of the Wnt/β|Catenin Signaling Pathway in ...

Epigenetic Regulation of the Wnt/β-Catenin Signaling Pathway in ...

Studies over the past four decades have elucidated the role of Wnt/β-catenin mediated regulation in cell proliferation, differentiation and ...

Epigenetic Regulation of the Wnt/β-Catenin Signaling Pathway in ...

Wnt signaling driven β-catenin acts as a molecular switch for the chromatin-associated high mobility group protein (HMG-17) to de-repress the inhibitory complex ...

Epigenetic Regulation of the Wnt/β-Catenin Signaling Pathway in ...

Apart from undergoing alterations at the genetic level, the Wnt signaling pathway components are dysregulated due to various ncRNAs and chromatin modifiers. In ...

Wnt/β-catenin signaling pathway safeguards epigenetic stability and ...

Wnt/β-catenin signaling has been investigated to be crucial for gene transcriptional regulation of mESCs, including pluripotency genes. Though, ...

Epigenetic regulation of Wnt-signaling pathway in acute ...

Abstract. Activation of the Wnt/β-catenin signaling pathway is a hallmark of a number of solid tumors. We analyzed the regulation of the ...

DACT3 Is an Epigenetic Regulator of Wnt/β-Catenin Signaling in ...

This work identifies an epigenetic component of Wnt/β-catenin regulation in colorectal cancer and thereby opens an important avenue for pharmacological ...

Epigenetic regulation of Wnt-signaling pathway in acute ...

Activation of the Wnt/β-catenin signaling pathway is a hallmark of a number of solid tumors. We analyzed the regulation of the Wnt/β-catenin ...

Epigenetic Regulation of the Wnt/β-Catenin Signaling Pathway in ...

In this review, we focus on the epigenetic players which influence the Wnt/β-catenin pathway via modulation of its components and coordinated regulation of the ...

Wnt/β-catenin signalling: function, biological mechanisms ... - Nature

The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis.

Molecular Pathways: Epigenetic Modulation of Wnt–Glycogen ...

Abstract. Aberrant regulation of the canonical Wnt signaling pathway (Wnt–β-catenin–GSK3 axis) has been a prevalent theme in cancer biology ...

Epigenetic Regulation of the Wnt/β-Catenin Signaling Pathway in ...

PDF | Studies over the past four decades have elucidated the role of Wnt/β-catenin mediated regulation in cell proliferation, differentiation and.

Epigenetic Activation of Wnt/β-Catenin Signaling in NAFLD ... - MDPI

Up to half of HCC patients have activation of Wnt/β-catenin signaling pathway [31,32,33]. When Wnt signaling is suppressed, generally due to a combination of ...

Epigenetic regulation of the Wnt-signaling pathway in CIMP-H ...

Conclusions: Genes under methylation regulation in the BRAF-mutant context showed enrichment in Wnt-signaling pathway. Since BRAFV600E CRC tumors have a low ...

Epigenetic regulation of the Hedgehog and Wnt pathways in cancer

Aberrant activation of these pathways by mutations in key pathway regulators contributes to the genesis and progression of several cancer types. In addition, ...

Wnt signaling in development and tissue homeostasis

Genetic or epigenetic events leading to hypo- or hyper-activation of the Wnt-β-catenin signaling cascade have also been associated with human ...

Wnt/β-catenin signaling pathway in carcinogenesis and cancer ...

Under normal physiological conditions, the Wnt/β-catenin signaling pathway is meticulously regulated. However, aberrant activation of this ...

WNT/β-Catenin Pathway and Epigenetic Mechanisms Regulate the ...

Importantly, WNT pathway dysregulation may be a component of neuropsy- chiatric disease pathology, as genetic variation at WNT signaling gene ...

SOX17 antagonizes WNT/β-catenin signaling pathway in ...

A role as a tumor suppressor gene was evaluated by colony formation assay and regulation of WNT/β-catenin signal pathway by SOX17 was determined by IHC and ...

The interaction of canonical Wnt/β-catenin signaling with protein ...

Also, SIRT1 can deacetylate β-catenin to block the transcription of Wnt-dependent genes and regulate cell differentiation [37,38,39]. In ...

Wnt/β-Catenin Signaling as a Molecular Target by Pathogenic Bacteria

The Wnt/β-catenin signaling pathway is crucial to regulate ... Role of bacterial infection in the epigenetic regulation of Wnt antagonist WIF1 by PRC2 protein ...