Epigenetic modifications driving ground state pluripotency exit ...

We demonstrate that regulation of pluripotency state by IκBα is independent of NF-κB but requires the chromatin-related IκBα function.

Genetic control of the pluripotency epigenome determines ... - NCBI

Cell cycle phase impacts exit from ground state pluripotency as an extended ... Genetic background induces distinct expression pattern changes across cell state ...

Chromatin features and the epigenetic regulation of pluripotency ...

In pluripotent stem cells, the interplay between signaling cues, epigenetic regulators and transcription factors orchestrates developmental potency. Flexibility ...

Epigenetic foundations of pluripotent stem cells that recapitulate in ...

Transcription factors (TFs) and epigenetic modifications, including DNA methylation and histone modifications, play a central role in these ...

bioRxiv na platformi X: „Epigenetic modifications driving ground ...

Epigenetic modifications driving ground state pluripotency exit require an NF-κB-independent chromatin IκBα function https://t.co/IeE7d9ajSX ...

Epigenetic dynamics during capacitation of naïve human pluripotent ...

Unexpectedly, PRC2 activity appeared to be dispensable for the capacitation. We find that capacitated hPSCs acquire an epigenetic state similar ...

DNA methylation and the core pluripotency network - ScienceDirect

Global DNA demethylation is observed in conventional murine ESCs 1–3 days after inducing the transition to the ground state (Ficz et al., 2013).

Chromatin and Epigenetic Rearrangements in Embryonic Stem Cell ...

Cells grown in 2iLIF also have an altered chromatin state and reduced levels of repressive marks; for example, H3K27me3 levels are reduced at developmental ...

Molecular versatility during pluripotency progression - Nature

To achieve these transitions, embryonic cells need to integrate complex sets of external cues and respond by precise epigenetic/transcriptomic ...

Spic regulates one-carbon metabolism and histone methylation in ...

Transition between different states of pluripotency is associated with global transcriptional and epigenetic reprogramming that restricts the ...

Reprogramming of cell fate: epigenetic memory and the erasure of ...

Successful iPS reprogramming thus requires removal of the somatic repressive chromatin to allow for conversion to a highly dynamic pluripotent chromatin state ...

Epigenetic control of transcriptional regulation in pluripotency and ...

A subset of TFs can reverse this inactive state by recruiting nucleosome remodeling complexes and histone modifying enzymes, resulting in an ...

Combinatorial metabolism drives the naive to primed pluripotent ...

Since epigenetic modifications are a key driver for cellular differentiation, the regulation of these modifications is tightly controlled.

The epigenetics of embryo development - Oxford Academic

Many genes in pluripotent ESC are associated with both the active (H3K4me3) and repressive (H3K27me3) epigenetic signatures. This bivalent state ...

TEAD2 initiates ground-state pluripotency by mediating chromatin ...

The transition of mouse embryonic stem cells (ESCs) between ground and confused state culture conditions unveils transcriptional networks ...

Regulatory Principles of Pluripotency: From the Ground State Up

In particular, we focus on the accumulating knowledge of the functional, epigenetic, and signaling properties that contribute to propagating ground state ...

Tracking the embryonic stem cell transition from ground state ...

Thus, we conclude that promoter methylation is not a major driver of transcriptional changes during exit from the naïve state, although it might contribute to ...

Activation of transcription factor circuity in 2i-induced ground state ...

By separating and defining their contributions, our data suggest that repressive epigenetic systems play minor roles in mESC self-renewal and naïve ground state ...

Ground State Conditions Induce Rapid Reorganization of Core ...

Request PDF | Ground State Conditions Induce Rapid Reorganization of Core Pluripotency Factor Binding before Global Epigenetic Reprogramming | Mouse ...

Regulatory Principles of Pluripotency: From the Ground State Up

during exit from pluripotency. Epigenetic Landscapes in Pluripotent States. DNA Modification. DNA methylation at CpG dinucleotides is a ...