Estimating and reporting treatment effects in clinical trials for weight ...

In the approval process for new weight management therapies, regulators typically require estimates of effect size.

... Estimating and reporting treatment effects in clinical trials for weight management: using estimands to interpret effects of intercurrent events and ...

Estimating and reporting treatment effects in clinical trials for weight ...

AbstractIn the approval process for new weight management therapies, regulators typically require estimates of effect size. Usually, as with other drug ...

Estimating and reporting treatment effects in clinical trials for weight ...

In the approval process for new weight management therapies, regulators typically require estimates of effect size. Usually, as with other drug evaluations, ...

How to estimate treatment effects from reports of clinical trials. I

Properly conducted randomised trials can aid clinical decision-making by providing unbiased estimates of the average size of treatment effects.

Report of a National Institutes of Health–Centers for Disease Control ...

Observational studies may be unable to provide convincing answers about the magnitude and direction of the health effects of intentional weight loss. Workshop ...

On the estimation of the effect of weight change on a health outcome ...

We utilised the target trial emulation framework and considered weight change as a hypothetical intervention. First, we used a simplified example from a ...

Once-Weekly Semaglutide in Adults with Overweight or Obesity

The coprimary end points were the percentage change in body weight and weight reduction of at least 5%. The primary estimand (a precise ...

Challenges of estimating treatment effects after a positive interim ...

We examined three challenges in interpreting treatment effects from randomized clinical trials (RCTs) after the first positive IA: overestimation bias; non- ...

International J Obesity в X: „Estimating and reporting treatment ...

Estimating and reporting treatment effects in clinical trials for weight management: using estimands to interpret effects of intercurrent events and missing ...

E 9 Statistical Principles for Clinical Trials Step 5

... clinical study report, and should approve the clinical ... evaluation of the results of a clinical trial to make the estimate of a treatment effect deviate.

Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo ...

Estimating and reporting treatment effects in clinical trials for weight management: using estimands to interpret effects of intercurrent ...

Semaglutide vs Tirzepatide for Weight Loss in Adults With ...

Estimating and reporting treatment effects in clinical trials for ... weight in randomized clinical trials, data from head-to-head ...

Tirzepatide Once Weekly for the Treatment of Obesity

Coprimary end points were the percentage change in weight from baseline and a weight reduction of 5% or more. The treatment-regimen estimand ...

ICH E9(R1) Estimands and Sensitivity Analysis in Clinical Trials ...

treatment effects that a clinical trial seek to estimate: o between ... from study reports, and the reported “treatment effect” can be misunderstood.

Guidance for Industry Developing Products for Weight Management

randomized, controlled trials on the effects of drug-induced weight loss on these clinical ... weight measurements but should estimate the treatment effect at the ...

The estimands framework: a primer on the ICH E9(R1) addendum

Estimand: A description of the exact treatment effect a study aims to quantify. Estimator: The statistical method used to compute the estimate ...

Eliminating Ambiguous Treatment Effects Using Estimands

Most reported treatment effects in medical research studies are ambiguously defined, which can lead to misinterpretation of study results. This is because most ...

How to estimate treatment effects from reports of clinical trials. I

This approach optimises clinical decision-making by combining unbiased estimates of the size of treatment effect from clinical trials with clinical intuition ...

National Estimates of the Participation of Patients With Cancer in ...

What is a contemporary estimate of enrollment to cancer treatment trials and other categories of cancer clinical research studies across a ...