Evidence for brain glucose dysregulation in Alzheimer's disease

Higher brain tissue glucose concentration, reduced glycolytic flux, and lower GLUT3 are related to severity of AD pathology and the expression of AD symptoms.

RESULTS. Higher brain tissue glucose concentration, reduced glycolytic flux, and lower GLUT3 are related to severity of AD pathology and the expression of AD ...

Evidence for brain glucose dysregulation in Alzheimer's disease

Highlights. •. Brain tissue glucose is associated with severity of Alzheimer's disease (AD) pathology and symptom onset. •. Reduced brain glycolytic flux is ...

Evidence for brain glucose dysregulation in Alzheimer's disease

Results: Higher brain tissue glucose concentration, reduced glycolytic flux, and lower GLUT3 are related to severity of AD pathology and the expression of AD ...

Glucose metabolism and AD: evidence for a potential diabetes type 3

Alzheimer's disease is the most prevalent cause of dementia in the elderly. Neuronal death and synaptic dysfunctions are considered the main ...

Brain metabolism in Alzheimer's disease: biological mechanisms of ...

AD patients have defects in hippocampal glucose metabolism prior to clinical manifestations. The impaired brain glucose uptake and reduced ...

A Systematic Review of Glucose Transport Alterations in Alzheimer's ...

However, there is accumulating evidence that hypometabolism occurs before the onset of brain atrophy and clinical symptoms, indicating that changes in ...

Evidence for Brain Glucose Dysregulation in Alzheimer's Disease

Higher brain tissue glucose concentration, reduced glycolytic flux, and lower GLUT3 are related to severity of AD pathology and the expression ...

Evidence for Brain Glucose Dysregulation in Alzheimer's Disease

RESULTS: Higher brain tissue glucose concentration, reduced glycolytic flux, and lower GLUT3 are related to severity of AD pathology and the ...

Low glucose induced Alzheimer's disease‐like biochemical ...

Evidence shows that detectable impairment of brain glucose metabolism occurs years before onset of AD symptoms and worsens with disease onset.

Hypometabolism, Alzheimer's Disease, and Possible Therapeutic ...

Studies have shown that AD is associated with decreased glucose uptake and utilization in the brain, which is thought to contribute to the decline in brain ...

Decoding Alzheimer's disease from perturbed cerebral glucose ...

Perturbed cerebral glucose metabolism, an invariant pathophysiological feature of AD, may be a critical contributor to the pathogenesis of this disease.

Higher Brain Glucose Levels May Mean More Severe Alzheimer's

For the first time, scientists have found a connection between abnormalities in how the brain breaks down glucose and the severity of the ...

Glycolytic Metabolism, Brain Resilience, and Alzheimer's Disease

Recent studies suggest that glycolytic metabolism, the cytoplasmic pathway of the breakdown of glucose, may play a critical role in the development of AD.

Elevation of brain glucose and polyol-pathway intermediates with ...

Impairment of brain-glucose uptake and brain-copper regulation occurs in Alzheimer's disease ... There was evidence for differences in glucose ...

Close Relationship of Alzheimer's Disease (AD) and Glucose ...

As for the relationship between glycemic control and dementia, the risk for developing dementia has been higher in the cases with severe hypoglycemic seizures.

Alzheimer's Disease is Type 3 Diabetes—Evidence Reviewed

14. Hoyer S. Causes and consequences of disturbances of cerebral glucose metabolism in sporadic Alzheimer disease: therapeutic implications. Adv Exp Med Biol.

Global Energy Metabolism Deficit in Alzheimer Disease Brain

Glucose-derived energy metabolites in the glycolytic and pentose phosphate pathway and the ketone body β-hydroxybutyrate were uniformly ...

(PDF) Altered O-GlcNAcylation and mitochondrial dysfunction, a ...

Compelling evidence suggests that brain glucose hypometabolism, preceding Alzheimer's disease hallmarks, is involved in the pathogenesis of Alzheimer's disease.

Dysfunctional Glucose Metabolism in Alzheimer's Disease Onset ...

Patients at risk show reduced glucose uptake in the brain. Additionally, type 2 diabetes mellitus increases the risk of AD with increasing age. Therefore, ...