Examining disease‐modifying roles of neurons in Alzheimer's ...

This study is set to determine neuron-autonomous changes in AD iPSC-derived neurons in vitro and in vivo.

Examining disease-modifying roles of neurons in Alzheimer's disease using a novel stem-cell-based human-mouse chimeric transplantation model. Wenhui Qu1,2.

Examining disease‐modifying roles of neurons in Alzheimer's ...

Request PDF | Examining disease‐modifying roles of neurons in Alzheimer's disease using a novel stem‐cell‐based human‐mouse chimeric transplantation model ...

Disease-Modifying Therapies for Alzheimer's Disease: More ...

Scientific advances over the last four decades have steadily infused the Alzheimer's disease (AD) field with great optimism that therapies targeting Aβ, amyloid ...

What Happens to the Brain in Alzheimer's Disease?

When TREM2 does not function normally, plaques build up between neurons. Astrocytes — another type of glial cell — are signaled to help clear ...

Approaches for studying neuroimmune interactions in Alzheimer's ...

Emerging studies demonstrate the crucial role of peripheral immune cells in shaping Alzheimer's disease (AD) pathology.

Role of Neuron and Glia in Alzheimer's Disease and Associated ...

Moreover, aging-dependent downregulation of astrocyte and microglial Aβ-degrading enzymes limits the neurotrophic and neurogenic role of glial cells and ...

Approaches for studying neuroimmune interactions in Alzheimer's ...

Peripheral immune cells play an important role in the pathology of Alzheimer's disease (AD), impacting processes such as amyloid and tau protein ...

The neuropathological diagnosis of Alzheimer's disease

Most importantly the neuritic plaques with dense amyloid and tau-positive neurites are believed to be closely associated with neuronal loss and ...

Recent advances in Alzheimer's disease: mechanisms, clinical trials ...

Overall, metal dyshomeostasis is closely linked to various events in AD such as amyloidosis, tauopathy, oxidative stress, and neuronal death.

An Expanded Narrative Review of Neurotransmitters on Alzheimer's ...

Inflammation plays a crucial role in the context of glutamate neurotransmission, interacting with neurons, astrocytes, and microglia. The ...

Alzheimer's Disease: Exploring the Landscape of Cognitive Decline

Individuals with Alzheimer's experience a progressive decline in cognitive function, memory loss, and changes in behavior and personality, ...

Modeling Alzheimer's disease with iPSC-derived brain cells - Nature

Many cellular functions perturbed in Alzheimer's disease can be recapitulated using iPSC-derived cells in vitro, and co-culture platforms are ...

Exploring non-canonical targets in Alzheimer's disease

These components are crucial for maintaining the integrity and proper function of neurons and the brain, playing key roles in the progression of ...

The neuroimmune axis of Alzheimer's disease - Genome Medicine

In this line and to specifically amplify Treg cell populations, treatment of APP/PS1 AD mice with low-dose peripheral IL-2 administration ...

Cell models for Alzheimer's and Parkinson's disease: At the interface ...

In cell models of neurodegenerative diseases, such an outcome can be observed as reduced neuronal death compared to the positive control, i.e., neuroprotection.

Scientists reveal cellular changes unique to early Alzheimer's disease

Knowing the molecular changes in neurons, glia, and other brain cells around plaques during the early phases of the disease could help ...

Comprehensive Review on Alzheimer's Disease: Causes and ...

Alois Alzheimer noticed a presence of amyloid plaques and a massive loss of neurons while examining the brain of his first patient that suffered from memory ...

Alzheimer Disease: Practice Essentials, Background, Anatomy

The mechanisms by which altered amyloid and tau protein metabolism, inflammation, oxidative stress, and hormonal changes may produce neuronal ...

The Role of NMDA Receptors in Alzheimer's Disease - Frontiers

Excitatory glutamatergic neurotransmission via NMDAR is critical for synaptic plasticity and survival of neurons. However, excessive NMDAR activity causes ...