Excitation/Inhibition Imbalance in Animal Models of Autism Spectrum ...

Imbalances between excitation and inhibition in synaptic transmission and neural circuits have been implicated in autism spectrum disorders.

Excitation/inhibition Imbalance in Animal Models of ASDs

Excitation and inhibition imbalances are frequently observed in animal models of autism spectrum disorders, and their correction normalizes key autistic ...

Excitation/Inhibition Modulators in Autism Spectrum Disorder

A theory of excitatory/inhibitory imbalance in ASD was proposed by Rubenstein and Merzenich (2003). This neurobiological model is based on the ...

Testing the excitation/inhibition imbalance hypothesis in a mouse ...

Excitation/inhibition (E/I) imbalance remains a widely discussed hypothesis in autism spectrum disorders (ASD). The presence of such an ...

Editorial: Targeting Excitation-Inhibition Imbalance in ... - Frontiers

E/I imbalances have been implicated in numerous brain and neurodevelopmental disorders, such as Autism Spectrum Disorders (ASDs). ASDs refer to a wide range of ...

Exploring the mechanisms underlying excitation/inhibition ...

Together, these data indicate that ASD-risk genes belonging to different gene ontologies can produce a similar electrophysiological phenotype ...

Intrinsic excitation-inhibition imbalance affects medial prefrontal ...

In autism we find that H is reduced, indicating increased excitation, in the medial prefrontal cortex (MPFC) of autistic males but not females.

Increased Excitation-Inhibition Ratio Stabilizes Synapse and Circuit ...

One long-standing model is that genetically distinct forms of ASD share a common increase in synaptic excitation to inhibition (E-I) ratio in ...

Daily oscillation of the excitation/inhibition ratio is disrupted in two ...

Alterations to the balance between excitation and inhibition (E/I ratio) are postulated to underlie behavioral phenotypes in autism spectrum ...

Excitation/Inhibition Imbalance in Animal Models of Autism Spectrum ...

Rubenstein, Model of autism: Increased ratio of excitation/inhibition in key neural systems, Genes Brain Behav, № 2, с. · Gogolla, Common circuit defect of ...

Modulation of prefrontal cortex excitation/inhibition balance rescues ...

Neurophysiological phenomena that underlie the symptoms of autism remain unclear. Genetics-based mouse models of autism have suggested that ...

Globally elevated excitation–inhibition ratio in children with autism ...

Altered neuronal excitation–inhibition (E–I) balance is strongly implicated in ASD. However, it is not known whether the direction and ...

Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism ...

Since this initial formulation, however, other studies have suggested a nearly opposite hypothesis; namely, that at least some Autism Spectrum Disorders (ASDs) ...

Targeting Excitation-Inhibition Imbalance in Neurodevelopmental ...

Such imbalances are frequently observed in animal models harboring genetic modifications of ASD‐associated genes, and their pharmacological correction has the ...

Autism may reflect excitation-inhibition imbalance in brain

To test the excitation-inhibition balance hypothesis, the Stanford scientists launched a set of experiments employing the mutant mice, which ...

Excitation/Inhibition Imbalance in Animal Models of Autism Spectrum ...

Excitation and inhibition imbalances are frequently observed in animal models of autism spectrum disorders, and their correction normalizes key autistic-like ...

Research Portal - From Genetic Animal Models to Human Patients

Key Determinants of Synaptic Excitation/Inhibition Imbalance in Autism Spectrum Disorders - From Genetic Animal Models to Human Patients ; info Type. Project.

Decoding excitation-inhibition imbalance from neuroimaging data in ...

Imbalance between excitatory and inhibitory signals in the brain (ie, E/I imbalance) has long been theorized as one of the primary pathophysiological ...

The signaling imbalance theory of autism, explained | The Transmitter

Several mouse models of autism or related conditions also show signaling imbalances. Some have too few inhibitory neurons. Some children ...

Beyond excitation/inhibition imbalance in multidimensional models ...

Computational modeling and analysis of mouse neural population data finds that the excitation/inhibition imbalance theory of brain disorders ...