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Expanding protein nanocages through designed symmetry|breaking


Expanding protein nanocages through designed symmetry-breaking

Expanding protein nanocages through designed symmetry-breaking. Sangmin Lee1,2,3,4, Ryan D. Kibler1,2, Quinton Dowling2,5, Yang Hsia1,2, Neil P. King1,2 ...

Design of a symmetry-broken tetrahedral protein cage by a method ...

Nonetheless, self-assembly design methods, whose successes are dramatically expanding due to modern machine learning algorithms,, generally give ...

Design of a symmetry-broken tetrahedral protein cage by a method ...

These have largely been based on highly symmetric forms exemplified by the Platonic solids. Prospective applications of protein cages would be expanded by ...

Design of four component T=4 tetrahedral, octahedral, and ... - bioRxiv

Design of four component T=4 tetrahedral, octahedral, and icosahedral protein nanocages through programmed symmetry breaking ... This article is a ...

Publications - Baker Lab

Expanding protein nanocages through designed symmetry-breaking Online. 2024. Abstract | Links. @online{Lee2024, title = {Expanding protein nanocages through ...

Assembly of Differently Sized Supercharged Protein Nanocages into ...

The assemblies created in this study further expand the repertoire of available protein scaffolds for nanoparticle assembly. Because the ...

Blueprinting extendable nanomaterials with standardized protein ...

... designed (Fig. 5a). Architectures with polyhedral nanocage symmetry can be similarly expanded provided that the linear THR propagation axis ...

The development of natural and designed protein nanocages for ...

Protein nanocages, usually assembled from multiple subunits in a high symmetry ... increasing interest in nano-encapsulation in food and medical fields.

Assembly of differently sized supercharged protein nanocages into ...

Abstract. This study focuses on the design and characterization of binary nanoparticle superlattices: Two differently sized, supercharged ...

Design of four component T=4 tetrahedral, octahedral, and ... - bioRxiv

Design of four component T=4 tetrahedral, octahedral, and icosahedral protein nanocages through programmed symmetry breaking. Sangmin Lee1,2 ...

Design of a symmetry‐broken tetrahedral protein cage by a method ...

Prospective applications of protein cages would be expanded by strategies for breaking the designed symmetry, for example, so that only one ...

Symmetry-Based Design of Protein Nano-Cages by Ajitha S. Cristie ...

Growing interest in protein nanocages also increases the demand for protein cages with new architectures and capabilities that go beyond the ones found in ...

Shape‐Anisotropic Assembly of Protein Nanocages with Identical ...

Thus, the interesting characteristics of the π–π stacking interactions and protein building blocks could provide a solution to design ...

Designed proteins assemble antibodies into modular nanocages

Computationally designed proteins drive the assembly of antibody nanocages in a range of architectures, allowing control of the symmetry and the antibody ...

Symmetry-Directed Design of Protein Cages and Protein Lattices ...

... protein nanocages can be fine-tuned by pH. By using the crystal ... Reconstructed ferritin nanocages with expanded 4-fold channels can self-assemble into ...

Improved interface packing and design opportunities revealed by ...

... by CryoEM analysis of a designed protein nanocage. Author links ... De novo symmetric protein complexes can be created through computational protein design ...

Engineering protein nanocages as carriers for biomedical applications

The design principles have led to the production of megadalton protein nanocages with icosahedral symmetry. ... extend their half-life ...

A prototype protein nanocage minimized from carboxysomes with ...

Considerable achievements in the design and assembly of PNCs with defined symmetry, size, and stability have been reported (5–7). However, ...

The development of natural and designed protein nanocages for ...

... proteins with special structures can be used as nanocarriers (120). Protein nanocages, usually assembled from multiple subunits in a high symmetry, are ...

Marsh Lab - Protein Cages - Google Sites

... protein that would be useful in a nanocage design. We utilize de novo designed coiled-coil proteins as small, simple symmetry elements. By fusing coiled ...