Experts Debate Bolus vs Continuous Infusion 5|FU

Experts Debate Bolus vs Continuous Infusion 5-FU - Cancer Network

Dr. Bertino said that 5-FU is activated by several pathways. Bolus 5-FU, which is active over 15 minutes to 24 hours, acts mainly by ...

Comparison of continuously infused 5-fluorouracil with bolus ...

... 5-fluorouracil chemotherapy administered as a continuous 120-hours infusion vs. intravenous bolus injection daily for 5 days demonstrated superiority of ...

Fluorouracil Bolus Use in Infusional Regimens Among Oncologists ...

003). In addition, more GI specialists remove 5-FU bolus when compared with generalists, but only in the metastatic setting (44% v 25%; OR, ...

A systematic review of the safety profile of bolus, continuous infusion ...

Despite differences in doses jeopardize the interpretation of results, this systematic review shows that 5-FU regimens with bolus and capecitabine are less ...

The Impact of Omitting 5-FU Bolus From mFOLFOX6 Chemotherapy ...

The differences in the 5-FU administration, as IV bolus or continuous infusion, result in different mechanisms of action of 5-FU. The bolus infusion of 5-FU ...

Randomized trial comparing monthly low-dose leucovorin and ...

experts on statistics in order to prevent bias, even if it ... with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced ...

Bolus 5-Fluorouracil as an Alternative in Patients with Cardiotoxicity ...

Of 305 cases, 74% of patients received 5-FU as a continuous infusion; 21% as bolus, 4% as intermediate infusion, 2.5% oral and 1% intraperitoneally. Overall, ...

Continuous infusion vs. intermittent bolus injection of furosemide in ...

In addition, a few studies have reported that continuous infusion correlated with lower mortality rate and shorter hospital stay compared with ...

A retrospective comparison of concurrent bolus 5-fluorouracil or ...

However, no significant differences were seen in sphincter preservation, pathologic complete response, local control and distant recurrences rates among ...

Omission of 5-Fluorouracil Bolus From Multidrug Regimens for ...

Background: 5-Fluorouracil (5-FU) is a major component of gastrointestinal cancer treatments. In multidrug regimens such as FOLFOX, FOLFIRI, ...

Impact of Empirically Eliminating 5-Fluorouracil Bolus and ...

Continuous 5-FU infusion was also associated with higher tumor response rates and improved median overall survival compared to 5-FU bolus (22% vs 14%; P = ...

Omitting 5-FU Bolus May Reduce Side Effects in Patients With ...

“This large study shows that omitting the bolus 5-FU has no detrimental effect on survival but reduces side effects and health-care costs,” she ...

Continuous Versus Bolus Infusion of Hypertonic Saline in the ...

Three percent saline bolus produces faster initial elevation of pNa than continuous infusion with quicker restoration of GCS, and without osmotic demyelination.

Infusional 5-FU: Historical Evolution, Rationale, and Clinical ...

Early clinical trials reported by Ansfield confirmed the importance of constant exposure to 5-fluorouracil (5-FU) to achieve a therapeutic ...

Bolus 5-fluorouracil (5-FU) In Combination With Oxaliplatin Is Safe ...

The two most likely contributors are ischemia due to coronary vasospasm and drug-related myocardial toxicity. ... A number of reports have confirmed that bolus 5- ...

Fluorouracil Bolus Use in Infusional Regimens Among Oncologists ...

... bolus) ad- ministration of 5-FU (400 mg/m2) on day 1 and then continuous 46-hour infusions of 5-FU (2,400 mg/m2) administered every 14 days ...

Effects of Bolus Injection of 5-Fluorouracil on Steady-State Plasma ...

Conclusion: A bolus of 5-FU on day 1 provided long-term exposure to 5-FU. Keywords: 5-fluorouracil, UFT, bolus injection, constant infusion, pharmacokinetics ...

Extended vs Bolus Infusion of Broad-Spectrum β-Lactams for Febrile ...

Overall response occurred in 35 (74.4%) patients treated with extended infusion and 32 (55.1%) patients treated with bolus infusion (P = .044). The superiority ...

Study Backs Skipping 5-FU Bolus in Chemo Regimens for ...

Omitting bolus 5-fluorouracil (5-FU) from combination chemotherapy for gastrointestinal (GI) cancers did not adversely affect survival and was associated with ...

Mortality of continuous infusion versus intermittent bolus ... - Frontiers

Our analysis indicated no significant difference between continuous infusion and intermittent bolus administration in adverse events (Figure 10) ...