Exploring the Potential of Biomimetic Peptides in Targeting Fibrillar ...

The peptides were designed using a peptide scrambling approach where antioxidant moieties were combined with fibrillary inhibition motifs in ...

Article Versions Notes - MDPI

Exploring the Potential of Biomimetic Peptides in Targeting Fibrillar and Filamentous Alpha-Synuclein—An In Silico and Experimental Approach to Parkinson's ...

Engineered Peptides Enable Biomimetic Route for Collagen ...

We developed a peptide-based approach enabling collagen intrafibrillar mineralization and tested our hypothesis on a type-I collagen-based platform. Peptide ...

Exploring cross-α amyloids: from functional roles to design innovations

... potential field. Section snippets. Self-assembly of proteins and peptides into amyloid fibrillar nanostructures. Self-assembly (see Glossary) ...

Peptide-Based Drug Delivery Systems - PMC - NCBI

Production of biomaterials fabricated via self-assembling of short peptides or their derivatives is a promising approach for creating novel ...

Biomimetic amplification of nanoparticle homing to tumors - PNAS

We describe here biomimetic particles that not only home to tumors, but also amplify their own homing. The system is based on a peptide that recognizes clotted ...

Peptide Self‐Assembly into Amyloid Fibrils at Hard and Soft ...

Peptides and proteins are exposed to a variety of interfaces in a physiological environment, such as cell membranes, protein nanoparticles ...

In situ editing of tumour cell membranes induces aggregation and ...

In this work, we develop a fibrillar-transformable peptide monomer (TPM)-based nanoparticle, for cancer immunotherapy upon in vivo biomimetic ...

Biomimetic design of fibril-forming non-immunogenic collagen like ...

These results accentuate the potential of designed CLP variants in tissue engineering, regenerative medicine and industrial sectors, supporting the development ...

Engineering of antimicrobial peptide fibrils with feedback ...

SANs were eliminated automatically by the gelatinase secreted from targeted bacteria. Our work provides a new strategy for rational design of ...

Exploring Peptido‐Nanocomposites in the Context of Amyloid ...

Accordingly, peptides and peptidomimetics can inhibit amyloid aggregation by stabilizing the proteins in their monomeric states, facilitating ...

Amphiphilic Histidine-Based Oligopeptides Exhibit pH-Reversible ...

Additionally, ensembles of peptides can undergo self-assembly into nanostructures with complex structure–function relationships including pores ...

Biomimetic peptide self-assembly for functional materials - 1 2

assembly of synthetic biomimetic peptides allows us to explore ... derived fibrils have real potential as components in novel biomimetic materials or as tools to.

A one-two punch targeting reactive oxygen species and fibril for ...

To explore the in vivo dual-targeted therapy function of Ang-NCs in ... Biomimetic dendrimer-peptide conjugates for early multi-target ...

Biomarker-activated multifunctional lysosome-targeting chimeras ...

However, unsatisfactory blood-brain barrier (BBB) permeability, potential off-target effects, and impaired protein degradation systems limit ...

Biomimetic Peptide Nanowires Designed for Conductivity

One of the reasons for choosing phenylalanine in the design of F6 was to enable aromatic molecular orbital overlap, potentially leading to ...

The diversity and utility of amyloid fibrils formed by short ... - Journals

This work provides a wide range of peptides that may be exploited as fibrous bionanomaterials. These fibrils provide a scaffold upon which ...

Exploring pathological link between antimicrobial and amyloid ...

This discovery introduces an innovative approach to explore and repurpose a diverse range of antimicrobial peptides that inherently possess both ...

Antimicrobial peptides: mechanism of action, activity and clinical ...

AMPs are divided into several subgroups on the basis of amino acid sequences, the net charge of the peptide, protein structure and sources ( ...

Biomimetic peptide self-assembly for functional materials

The self-assembly of synthetic biomimetic peptides thus allows the exploration of chemical and sequence space beyond that used routinely by biology. In this ...