FROM GENETIC RISK FACTORS TO MENDELIAN CAUSATIVE ...

Beyond Mendelian randomization: how to interpret evidence of ...

Mendelian randomization is a popular technique for assessing and estimating the causal effects of risk factors. If genetic variants which are instrumental ...

Selecting likely causal risk factors from high-throughput experiments ...

Mendelian randomization (MR) is the use of genetic variants as instrumental variables to infer the causal effect of a specific risk factor on an ...

Inferring Causal Relationships Between Risk Factors and Outcomes ...

We review the Mendelian randomization paradigm for making causal inferences using genetic variants. We consider monogenic analysis, in which genetic variants ...

Genetic Risk Factor - an overview | ScienceDirect Topics

Genetic risk factors are increasingly being recognized as having a significant role in many diseases of public health importance.

Reading Mendelian randomisation studies: a guide, glossary, and ...

Mendelian randomisation is an analytical method that uses genetic variants as instrumental variables for modifiable risk factors that affect ...

Causal associations between risk factors and common diseases ...

Mendelian randomization (MR) is an analysis that uses genetic variants, which are expected to be independent of confounding factors, as ...

Inferring Causal Relationships Between Risk Factors and Outcomes ...

We review the Mendelian randomization paradigm for making causal inferences using genetic variants. We consider monogenic analysis, in which ...

The Use of Pleiotropic Genetic Variants to Estimate Causal Effects ...

A conventional Mendelian randomization analysis assesses the causal effect of a risk factor on an outcome by using genetic variants that are ...

Genetic Associations Between Modifiable Risk Factors and ...

Design, Setting, and Participants This genetic association study was conducted using 2-sample univariable and multivariable mendelian ...

Causal inference for heritable phenotypic risk factors using ... - PLOS

The phenomenon that “all genes affect every complex trait” complicates Mendelian Randomization (MR) studies, where natural genetic variations are used as ...

Genetic association and causal relationship between multiple ...

Genetic association and causal relationship between multiple modifiable risk factors and autoimmune liver disease: a two-sample mendelian ...

Using published data in Mendelian randomization: a blueprint for ...

By considering the genetic associations with each of the risk factors in a single model, the causal effects of each of the risk factors on the ...

Mendelian randomization: genetic anchors for causal inference in ...

In MR studies, genetic variants are taken to be proxy indicators of modifiable factors that potentially influence disease risk. The manner in which the variants ...

Causal Association of Cardiovascular Risk Factors and Lifestyle ...

By adhering to these assumptions the genetic variant is not directly associated with the outcome, nor is there any alternative pathway by which ...

A Metabolome-Wide Mendelian Randomization Study Identifies ...

However, the precise causal genes ... 7. Zhu, Z. ∙ Zheng, Z. ∙ Zhang, F. ... Causal associations between risk factors and common diseases inferred from GWAS ...

Appraising the Causal Role of Risk Factors in Coronary Artery ...

The Mendelian randomization (MR) approach can potentially overcome some biases of traditional epidemiological research by using genetic variants ...

Causal associations between modifiable risk factors and pancreatitis

Genome-wide association studies (GWASs) of individuals of European ancestry were selected as data sources for genetic instruments associated ...

A Mendelian Randomization Analysis Investigates Causal ... - MDPI

A total of 37 primary risk factors were selected and classified into eight categories: exposure to drugs, lifestyle behaviors, surgeries, related diseases, ...

An atlas on risk factors for type 2 diabetes: a wide-angled Mendelian ...

Utilising genetic variants as instrumental variables for an exposure, Mendelian randomisation (MR) analysis can strengthen the causal inference ...

Causal mediation analysis for time-varying heritable risk factors with ...

When randomized controlled experiments are not available, Mendelian Randomization (MR) offers an alternative, leveraging genetic mutations as a ...