Familial rare EGFR|mutant lung cancer syndrome

Familial rare EGFR-mutant lung cancer syndrome - PubMed

Although rare, germline p.R776H EGFR lung cancer mutations are over-represented in light or never smoking female patients who often also possess an ...

Familial rare EGFR-mutant lung cancer syndrome - ScienceDirect.com

A family of 3 sisters with lung cancer and their unaffected mother all with a rare EGFR germline mutation (EGFR p.R776H).

Germline EGFR Mutations and Familial Lung Cancer

This syndrome is one of few inherited cancer syndromes in which the pathogenic germline variant is in an oncogene (not a tumor suppressor gene).

Hereditary lung cancer syndrome targets never smokers with ...

Germline T790M mutations are rare, and, with the exception of family member testing, are almost always detected during analysis of lung cancers for EGFR ...

First Prospective Description of Familial EGFR-mutated Lung Cancer

Lung cancers in germline carriers commonly carried a somatic driver EGFR mutation and had favourable outcomes on osimertinib. Genome-wide ...

Inherited lung cancer syndromes targeting never smokers - Yamamoto

Most of lung cancers develop sporadically and thus inherited lung cancers are rare. Several reports show that germline mutations in the kinase domain of ...

Hereditary Cancer - Lung Cancer Research

Interestingly, the best described germline EGFR mutation (T790M) is similarly rare in lung cancer patients at diagnosis. A recent study has found that 5 of ...

Germline EGFR mutations in lung cancer (Review)

However, the germline T790M mutation is rare, found in only 1% of patients with lung cancer whose EGFR gene has been sequenced, and in ~50% of ...

Developmental mosaicism underlying EGFR-mutant lung cancer ...

However, we previously identified a family with inherited susceptibility to EGFR-mutant lung cancer, caused by a germline variant with ...

EGFR and Lung Cancer | American Lung Association

A mutation in the EGFR gene is one biomarker that physicians look for in non-small cell lung cancer.

Potential genetic modifiers for somatic EGFR mutation in lung cancer

Familial lung cancers more likely have concurrent EGFR mutations along with mutations in their germline cancer predisposition genes including ...

Predisposition to Lung Adenocarcinoma in a Family Harboring the ...

Most EGFR mutations occur in somatic tumor tissue, with germline EGFR mutations being extremely rare. ... As a scarce example, the germline EGFR ...

From Rarity to Reality: Osimertinib's Promising Horizon in Treating ...

In the realm of advanced non–small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) therapy with tyrosine kinase ...

EGFR mutation lung cancer: Definition, outlook, treatment, and more

Instead, EGFR mutation lung cancer will show symptoms of the overall type of lung cancer to which is it connected. According to the ACS, most lung cancers do ...

Novel therapeutic strategies for rare mutations in non-small cell lung ...

BRAF mutations can be found in various tumors, and the most common tumor is melanoma. Approximately 2–4% of NSCLC patients have BRAF gene ...

Presentation of EGFR mutations in 162 family probands with ...

Lung cancers with specific somatic EGFR mutations have a favorable clinical response to EGFR-tyrosine kinase inhibitors (TKIs) (16-18). The most frequent EGFR ...

Inherited lung cancer: a review - ecancer

This mutation is rare, but EGFR is considered to be a major cancer predisposition gene, associated with an estimated 31% risk of lung cancer ...

Lung cancer is also a hereditary disease

EGFR variants, T790M in particular, cause the EGFR susceptibility syndrome. Risk seems limited to lung cancer. Emerging data suggest that variants in ATM, the ...

EGFR Mutations in Non–Small-Cell Lung Cancer - JAMA Network

These activating EGFR mutations are associated with high response rates to EGFR tyrosine kinase inhibitor (TKI) therapy, with combined results ...

Detection of rare and novel EGFR mutations in NSCLC patients

Objectives: Mutations in the gene that encodes epidermal growth factor receptor (EGFR) are biomarkers that predict how non-small cell lung cancer (NSCLC) ...