Fig. 3 proNGF enhances trans|BBB migration through Src activation...

ProNGF promotes brain metastasis through TrkA/EphA2 induced Src ...

proNGF enhances trans-BBB migration through Src activation independently of TrkA phosphorylation in TNBC. ... through the endothelium (Fig ...

Fig. 3 proNGF enhances trans-BBB migration through Src activation...

Download scientific diagram | proNGF enhances trans-BBB migration through Src activation independently of TrkA phosphorylation in TNBC.

(PDF) ProNGF promotes brain metastasis through TrkA/EphA2 ...

ArticlePDF Available. ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in ... proNGF induces BBB transmigration through ...

Pro-nerve Growth Factor Induces Autocrine Stimulation of Breast ...

... activation of Akt induced by proNGF as well as its proinvasive effect (Fig. 3E), suggesting that a proNGF/sortilin interaction is necessary for TrkA activation.

ProNGF increases breast tumor aggressiveness through functional ...

ProNGF-induced Src activation through EphA2 is independent of TrkA phosphorylation. ... migration (Tsouko et al., 2015) (Fig. 2). Show ...

NGF and ProNGF: Regulation of neuronal and neoplastic responses ...

In the main, RTKs stimulate three main pathways: the activation of ERKs via ... migration and invasion via the activation of Src and Akt. ProNGF as an ...

[PDF] NGF-induced TrkA/CD44 association is involved in tumor ...

ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells ... proNGF induces BBB transmigration through ...

The role of crosstalk between cerebral immune cells and peripheral ...

Fig. 1. Activation of CICs and their effects on the integrity of the BBB after ICH. CICs are activated by different molecules and hematoma components after ...

From Neural Crest Development to Cancer and Vice Versa - Frontiers

FIGURE 4 | In some cases, migration and invasion are stimulated through NGF or proNGF upon activation of p75NTR and TrkA. Two main pathways are ...

The neurotrophic tyrosine kinase receptor TrkA and its ligand NGF ...

... activated in neurons and including ERK, SRC and AKT. Recent ... ProNGF was also increased in malignant tissue (Fig. 3B–E) compared to ...

The nerve growth factor-delivered signals in prostate cancer and its ...

... in sustaining the proliferative or migratory phenotype of PC cells. As such, TrkA might undergo activation upon a local increase in androgen ...

Pro-Nerve Growth Factor Induced RhoA Kinase Activation in PC12 ...

Intracellular proNGF is cleaved by furin in the trans ... Although poorly understood, it is believed that p75NTR activation by proNGF promotes ... pathway via RhoA ...

ProNGF, but Not NGF, Switches from Neurotrophic to Apoptotic ...

... proNGF remained intact during the experiment (Figure 3E). These results ... NGF and proNGF also mediate cancer pain through activation of TrkA on ...

Pre-Clinical and Clinical Applications of Small - ProQuest

Pancreatic cancer (PC) is one of the leading causes of death and is the fourth most malignant tumor in men. The epigenetic and genetic alterations appear to ...

The GDNF family: Signalling, biological functions and therapeutic ...

Neurotrophins activate, through their Trk receptors, the phosphatidylinositol 3 ... during early embryonic development (Fig. 4) ... promotes the migration ...

Src kinase modulates the activation, transport and signalling ...

The non‐receptor tyrosine kinase Src is recruited to activated fibroblast growth factor receptor (FGFR) complexes through the adaptor protein factor ...

Pre-Clinical and Clinical Applications of Small Interfering RNAs ...

Pancreatic cancer (PC) is one of the leading causes of death and is the fourth most malignant tumor in men. The epigenetic and genetic alterations appear to ...

Syntaxin-1A, a synaptic-related protein in breast and ... - Dipòsit Digital

SYNTAXIN-1A PROMOTES MIGRATION IN BC AND HNSCC ... Representative Western blot analysis of AKT and ERK activation in SK-BR-3 (A), ... seen in cell adhesion and ...

UNIVERSITÀ DEGLI STUDI DELL'AQUILA - IRIS

Neurotrophins (NTs), the proteins involved in survival and growth of neuronal and no neuronal cell types, and vascular endothelial growth factor (VEGF), ...

Recent advances in pharmacological diversification of Src family ...

Mechanism. As shown in Fig. 3, the activation segment present on the Src tyrosine kinase enzyme is Y419 that is Tyr419, which promotes kinase ...