First|in|human phase I study of infusional and bolus schedules of ...

First-in-human phase I study of infusional and bolus schedules of ...

Deflexifol is safer and effective in bolus and infusion schedules at higher doses than that permitted by separate infusion of 5-FU and LV. A phase II study ...

First‐in‐human phase I study of infusional and bolus schedules of ...

Conclusion. Deflexifol is safer and effective in bolus and infusion schedules at higher doses than that permitted by separate infusion of 5-FU ...

First-in-human phase I study of infusional and bolus schedules of ...

(2019). First-in-human phase I study of infusional and bolus schedules of Deflexifol, a novel 5-fluorouracil and leucovorin formulation, after failure of ...

First‐in‐human phase I study of infusional and bolus schedules of ...

Deflexifol is safer and effective in bolus and infusion schedules at higher doses than that permitted by separate infusion of 5-FU and LV. A ...

(PDF) First‐in‐human phase I study of infusional and bolus ...

The recommended phase II infusional dose was declared as 3,000 mg/m², >25% that of 5‐FU used in standard‐of‐care regimens. Pharmacokinetic analyses showed ...

Publications - FivepHusion

5-FU/LV co-infusion rationale; Colorectal cancer; Ependymoma. Deflexifol™ Publications. First-in-human phase I study of infusional and bolus schedules of ...

Deflexifol (a novel formulation of 5FU): Phase 1 dose escalation ...

Deflexifol (a novel formulation of 5FU): Phase 1 dose escalation study of infusional and bolus schedules after failure of standard treatment.

A phase I dose-escalation study of an all-in-one 5-fluorouracil and ...

This subsequent phase I study sought to investigate Deflexifol administered as a combined bolus and infusion schedule. Methods: Patients with advanced ...

Phase I study of ZD9331 on short daily intravenous bolus infusion ...

Phase I study of ZD9331 on short daily intravenous bolus infusion for 5 days every 3 weeks with fixed dosing recommendations · Authors · Affiliation.

Experts Debate Bolus vs Continuous Infusion 5-FU - Cancer Network

Dr. Diasio pointed out that a continuous infusion schedule produces more complete responses (5% vs 0% with bolus 5-FU in one study) and a higher ...

Dose intensity for bolus versus infusion chemotherapy administration

Infusional schedules were defined as continuous parenteral administration for more than 24 hours or, in some instances, daily bolus dosing for one hour for 3 to ...

Phase I Study of Continuous-Infusion l - S,R -Buthionine Sulfoximine ...

BSO was administered as an initial 30-minute infusion (a fixed dose of 3.0 g/m 2 ) followed immediately by a continuous infusion lasting 24–72 hours. During ...

A randomized phase II trial of irinotecan in combination with ...

As a result, CPT-11 in combination with either bolus 5-FU/FA or an infusional 5-FU/FA regimen has been approved for the first-line treatment of patients with ...

Comparison of Continuous Infusions and Bolus Injections of 5 ...

Mulder, A Phase I-II Study of 14-days Continuous Infusion of 5-Fluorouracil with Weekly Bolus Leucovorin in Metastatic Colorectal Carcinoma, Eur. J. Cancer 28A: ...

Infusional 5-FU: Historical Evolution, Rationale, and Clinical ...

Phase III Comparative Trials with Infusional vs Bolus 5-FU ... The study by Rougier et al, involving 155 patients, has only been reported in ...

Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is ...

Infused 5-FU given over 12 weeks resulted in similar survival to bolus 5-FU and FA over a 6 month period, but with significantly less toxicity.

Should we still be using bolus 5-FU prior to infusional regimens in ...

The true clinical value of bolus 5-FU right before infusional regimens remains to be determined since no randomized trials have addressed this issue.

ISRCTN - ISRCTN98405441: Adjuvant therapy: colorectal cancer ...

1. Differences in toxicity profile, adverse events and quality of life in bolus and infusional treatment regimens. The aim is to develop a new adjuvant ...

Phase II Study of a Weekly 8-Hour 5-Fluorouracil and Leucovorin ...

Efficacy of intravenous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. J Clin Oncol. 1998. ;. 16. : 301. –8.

Phase III Study of Bolus Versus Infusion Fluorouracil With or Without ...

The protocol was approved by the Cancer. Therapy Evaluation Program of the National Cancer. Institute, the Food and Drug Administration, and the. Human ...