Flap endonuclease 1 repairs DNA|protein crosslinks via ...

Flap endonuclease 1 repairs DNA-protein crosslinks via ADP ...

We showed that FEN1 repairs FA-induced DPCs in vivo and cleaves 5'-flap DNA substrate harboring DPC mimetic in vitro.

[PDF] Flap endonuclease 1 repairs DNA-protein crosslinks via ADP ...

Flap endonuclease 1 repairs DNA-protein crosslinks via ADP-ribosylation · Yilun Sun, Lisa M. Jenkins, +10 authors. Y. Pommier · Published in bioRxiv 19 October ...

Flap endonuclease 1 repairs DNA-protein crosslinks via ADP ...

Request PDF | Flap endonuclease 1 repairs DNA-protein crosslinks via ADP-ribosylation | DNA-protein crosslinks (DPCs) are among the most ubiquitous and ...

The prognostic significance of Flap Endonuclease 1 (FEN1) in ...

Impaired DNA repair mechanism is one of the cancer hallmarks. Flap Endonuclease 1 (FEN1) is essential for genomic integrity. FEN1 has key roles during base ...

The flap endonuclease-1 mediated maturation of Okazaki fragments ...

Recently, FEN1 has also been shown to repair formaldehyde-induced DNA protein crosslinks via ADP-ribosylation [34]. Okazaki fragments, short ...

Involvement of Flap Endonuclease 1 in Base Excision DNA Repair

Using a reconstituted system with the proteins derived from Xenopus laevis, we found that flap endonuclease 1 (FEN1) was a factor responsible for the excision ...

BER-generated DNA-protein crosslinks to oxidative lesions

Lesions such as 2-deoxypentos-4-ulose can be removed by conventional (single-nucleotide) BER, which proceeds through a covalent Schiff base intermediate with ...

PARP1-driven repair of topoisomerase IIIα DNA-protein crosslinks ...

... repair and provide evidence that poly(ADP-ribose) polymerase 1 (PARP1) drives the repair of TOP3A-DPCs by recruiting flap endonuclease 1 (FEN1) to the TOP3A- ...

Phosphate steering by Flap Endonuclease 1 promotes 5 - Nature

DNA replication and repair enzyme Flap Endonuclease 1 (FEN1) is vital for genome integrity, and FEN1 mutations arise in multiple cancers.

Flap Endonuclease 1 Endonucleolytically Processes RNA to ... - MDPI

Flap endonuclease 1 (FEN1) is an essential enzyme that removes RNA primers and base lesions during DNA lagging strand maturation and ...

DNA Repair Endonucleases: Physiological Roles and Potential as ...

The heterodimer endonuclease complex “excision repair cross complementing group 1 ... ∙ Hübscher, U. Flap Endonuclease 1: A Novel Tumour Suppresser Protein.

Flap Endonuclease 1 Efficiently Cleaves Base Excision Repair and ...

Flap Endonuclease 1 (FEN1) plays important roles both in DNA replication and in base excision repair (BER). However, in both processes FEN1 substrates are ...

Flap endonuclease 1 and DNA-PKcs synergistically participate in ...

Synthetic lethality strategies provide a novel scenario to anticancer therapy with DNA repair protein mutation, such as glioma with DNA-PKcs- ...

Apurinic/Apyrimidinic Endonuclease 1 and Tyrosyl-DNA ... - Frontiers

Bifunctional 8-oxoguanine-DNA glycosylase (OGG1), a crucial DNA-repair enzyme, removes from DNA 8-oxo-7,8-dihydroguanine (8-oxoG) with following cleavage of the ...

Functional regulation of FEN1 nuclease and its link to cancer

Flap endonuclease-1 (FEN1) is a member of the Rad2 structure-specific nuclease family. FEN1 possesses FEN, 5′-exonuclease and gap-endonuclease activities. The ...

FEN1 - Flap endonuclease 1 - Homo sapiens (Human) - UniProt

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication ...

Kinetics of endogenous mouse FEN1 in base excision repair

The structure specific flap endonuclease 1 (FEN1) plays an essential role in long-patch base excision repair (BER) and in DNA replication. We have generated a ...

Replication and Damage Repair of Flap Endonuclease 1 in ...

In response to UV irradiation and upon phosphorylation, FEN1 migrates to nuclear plasma to participate in the resolution of UV cross-links on DNA, most likely ...

Fen1 (flap-endonuclease) is an important enzyme function ... - Brainly

Fen1 or flap-endonuclease 1 is a critical enzyme in eukaryotic DNA replication. It functions to remove RNA primers used in Okazaki fragment ...

Small molecule inhibitors uncover synthetic genetic interactions of ...

Flap endonuclease 1 (FEN1) is a structure selective endonuclease required for proficient DNA replication and the repair of DNA damage.