Formation and repair of DNA|protein crosslink damage

Formation and Repair of DNA-Protein Crosslink Damage - PMC

DNA is constantly exposed to a wide array of genotoxic agents, generating a variety of forms of DNA damage. DNA-protein crosslinks (DPCs) – the covalent ...

Formation and repair of DNA-protein crosslink damage - PubMed

DNA is constantly exposed to a wide array of genotoxic agents, generating a variety of forms of DNA damage. DNA-protein crosslinks (DPCs)-the covalent ...

DNA–protein cross-link repair: what do we know now?

When a protein is covalently and irreversibly bound to DNA (i.e., a DNA–protein cross-link [DPC]), it may obstruct any DNA-based transaction ...

Formation and repair of DNA-protein crosslink damage - SpringerLink

DNA is constantly exposed to a wide array of genotoxic agents, generating a variety of forms of DNA damage. DNA-protein crosslinks ...

Mechanisms and Regulation of DNA-Protein Crosslink Repair ...

Covalent crosslinking of proteins to DNA upon damage or at DNA breaks causes the formation of highly variable, bulky lesions known as DNA-protein crosslinks.

Mechanisms of DNA−protein cross-link formation and repair

Numerous proteins bind to DNA for replication, transcription, and damage repair. ... DNA-peptide cross-links through canonical DNA damage response pathways.

Editorial: The repair of DNA–protein crosslinks - Frontiers

DNA–protein crosslinks (DPCs) are among the most ubiquitous and heterogenous lesions that arise from the covalent linking of a protein with a ...

Formation and repair of DNA-protein crosslink damage - SciEngine

DNA is constantly exposed to a wide array of genotoxic agents, generating a variety of forms of DNA damage. DNA-protein crosslinks (DPCs)—the covalent ...

Ubiquitin signaling and the proteasome drive human DNA–protein ...

Enhanced DNA repair capability represents a potential avenue through which cancer cells become resistant towards DNA–protein crosslink (DPC) ...

Transcription-coupled repair of DNA–protein cross-links depends on ...

Covalent DNA–protein cross-links (DPCs) are toxic DNA lesions that block replication and require repair by multiple pathways.

How to fix DNA-protein crosslinks - ScienceDirect.com

The large diversity of DPCs suggests that there is more than one canonical mechanism to repair them. Indeed, many different enzymes have been shown to act on ...

Formation and repair of DNA-protein crosslink damage

DNA is constantly exposed to a wide array of genotoxic agents, generating a variety of forms of DNA damage. DNA-protein crosslinks ...

Isolation and detection of DNA–protein crosslinks in mammalian cells

If not rapidly repaired, DPCs create obstacles that disturb DNA replication, transcription and DNA damage repair, ultimately leading to genome ...

Formation, Repair, and Biological Effects of DNA–Protein Cross-Link ...

However, exposure of cells to DNA-damaging agents can cause proteins to become covalently trapped on DNA, generating DNA–protein cross-links ( ...

Enzymatic Processing of DNA–Protein Crosslinks - MDPI

DNA–protein crosslinks (DPCs) represent a unique and complex form of DNA damage formed by covalent attachment of proteins to DNA. DPCs are formed through a ...

Crosslinking of DNA - Wikipedia

In genetics, crosslinking of DNA occurs when various exogenous or endogenous agents react with two nucleotides of DNA, forming a covalent linkage between ...

DNA-Protein Cross-Links: New Insights into their Formation and ...

DNA-protein cross-links (DPCs) were first recognized as a distinct lesion in ultraviolet light (UV)-irradiated bacteria by Smith1 and by Alexander and Moroson.

Mechanisms of DNA−protein cross-link formation and repair

... Protein-DNA crosslinks can be repaired by proteasomal activity that digests the bulky protein adducts to the peptide level to allow the canonical repair ...

Incision of DNA–protein crosslinks by UvrABC nuclease suggests a ...

DNA–protein crosslinks (DPCs) arise in biological systems as a result of exposure to a variety of chemical and physical agents, many of which are known or ...

DNA–Protein Crosslink Proteolysis Repair - Cell Press

Proteins that are covalently bound to DNA constitute a specific type of DNA lesion known as DNA–protein crosslinks (DPCs).