Functional SARS|CoV|2 cross|reactive CD4 T cells established in ...

Functional SARS-CoV-2 cross-reactive CD4+ T cells established in ...

Here, we provide evidence that functional cross-reactive memory CD4+ T cell immunity against severe acute respiratory syndrome coronavirus 2 ( ...

Functional SARS-CoV-2 cross-reactive CD4+ T cells established in ...

Pre-existing SARS-CoV-2-reactive T cells have been identified in SARS-CoV-2-unexposed individuals, potentially modulating COVID-19 and ...

Functional characterization of CD4+ T cell receptors crossreactive ...

We identified and characterized the TCR clonality and functional avidity of memory T cells crossreactive for the spike glycoprotein (S) of both SARS-CoV-2 and ...

Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune ...

We also examined the functional avidities of HCoV-reactive CD4+ T cells (Fig. 3B). High frequencies of CD3lo T cells were found among both HCoV- ...

Cross-reactive memory T cells associate with protection against ...

Bacher et al., observed low affinity huCoV spike-specific CD4 T cells had low functional avidity against SARS-CoV-2 in COVID-19 patients, ...

Comprehensive Analysis of CD4 + T Cell Response Cross-Reactive ...

2G (RRID: Addgene_12259), and 1.64 pmol single HLA class II allele-encoding pCDH, and the supernatant was harvested after 2 days. The K562-based ...

The impact of pre-existing cross-reactive immunity on SARS-CoV-2 ...

... functional cross-reactivity than found in children. The frequency of high-avidity and functional CD4+ T cells, cross-reactive with SARS-CoV ...

T cell response to intact SARS-CoV-2 includes coronavirus cross ...

Resultant CD8 T cells recognize SARS-CoV-2–infected respiratory tract cells, and CD4 T cells detect inactivated whole viral antigen.

Lack of memory recall in human CD4 T cells elicited by the first ...

Here, we quantify responses toward all the viral classes by cytokine secretion assays, stressing the functionality of the SARS-CoV-2 reactive ...

Pre-existing SARS-CoV-2-reactive CD4 +T cells are established and ...

Using flow cytometry, the phenotype and function of seasonal coronavirus OC43-specific and pre-existing SARS-CoV-2-reactive memory (m) CD4 +T ...

Functional SARS-CoV-2 cross-reactive CD4 + T cells ... - NASA ADS

Our results provide evidence that functional pre-existing SARS-CoV-2-reactive memory CD4 + T cells are elicited in early childhood and linked to ...

Post-pandemic memory T cell response to SARS-CoV-2 is durable ...

Comparable results to post-Omicron-infected participants were found, demonstrating that spike-specific T cell responses were highly cross- ...

(PDF) Functional SARS-CoV-2 cross-reactive CD4+ T cells ...

located primarily within the structural and functional proteins (5, 6, 11, 12). In response to SARS-CoV-2 infection, lower magnitudes of SARS- ...

SARS-CoV-2 vaccination diversifies the CD4+ spike-reactive T cell ...

which is a recently developed functional T cell assay that identifies antigen-specific T cell receptor (TCR) clonotypes (Figures 1, and S1, S2).

SARS-CoV-2-specific CD4+ and CD8+ T cell responses can ... - eLife

However, based on the relatively high frequency and prevalence of cross-reactive T cells, we hypothesized cytomegalovirus (CMV) may induce these ...

SARS-CoV-2–specific T cells in unexposed adults display broad ...

T cell clones generated from tetramer-labeled cells cross-reacted with antigens from commensal bacteria in the skin and gastrointestinal tract.

Distinct T cell polyfunctional profile in SARS-CoV-2 seronegative ...

Mikaeloff, et al. Functional SARS-CoV-2 cross-reactive CD4 + T cells established in early childhood decline with age. Proc. Natl. Acad. Sci ...

Assessment of T-cell Reactivity to the SARS-CoV-2 Omicron Variant ...

... CD4+ and CD8+ T-cell activation and function. While we observed a significant reduction in T-cell reactivity to the mutated regions of the ...

SARS-CoV-2 breakthrough infection in vaccinees induces virus ...

... CoV-2–specific T cells were CD4+ or CD8+. Nasal samples were ... SARS-CoV-2 cross-reactive T cells can have lower affinity to SARS ...

High frequencies of alpha common cold coronavirus/SARS-CoV-2 ...

This study compares the antigen specificity, frequency, phenotype, and function of cross-reactive memory CD4 + and CD8 + T cells between common cold ...