Functions of RANKL/RANK/OPG in bone modeling and remodeling

The discovery of the RANKL/RANK/OPG system in the mid 1990s for the regulation of bone resorption has led to major advances in our ...

RANKL/RANK signaling regulates osteoclast formation, activation and survival in normal bone modeling and remodeling and in a variety of pathologic conditions ...

RANKL/RANK/OPG system beyond bone remodeling

Hence, OPG prevents RANKL from binding to its receptor RANK, inhibiting osteoclastogenesis and protecting the bone from excessive osteoclast- ...

Bone Signaling & RANKL - Basic Science - Orthobullets

central to this process is the RANK/RANKL/OPG pathway ... blocking of RANKL by OPG results in decreased skeletal metastasis in animal models.

RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise ...

The RANKL/RANK/OPG system is known for its roles in osteoclasts maturation, bone modeling, and bone remodeling. Receptor activator of NF-kB ( ...

The RANK/RANKL/OPG system and tumor bone metastasis - Frontiers

OPG is known as a decoy receptor for RANKL, which can effectively inhibit RANKL-RANK interaction and mediate bone remodeling (14). RANKL is ...

The Roles of RANK/RANKL/OPG in Cardiac, Skeletal, and Smooth ...

Osteoblast membrane-bound RANKL binds to RANK at the surface of osteoclast progenitor cells to stimulate osteoclastogenesis, bone remodeling, ...

RANKL - Wikipedia

RANKL is an apoptosis regulator gene, a binding partner of osteoprotegerin (OPG), a ligand for the receptor RANK and controls cell proliferation.

Mapping RANKL- and OPG-expressing cells in bone tissue ... - Nature

OPG:Fc treatment in mice induced an increased expression of RANKL mRNA mainly in trabecular, but not endocortical bone surface cells.

RANK/RANKL/OPG (receptor activator of nuclear factor-kB/RANK ...

The RANK/RANKL/OPG system regulates bone matrix modeling and remodeling pathways and contributes to muscle pathophysiology in DMD. Furthermore, RANK, RANKL, and ...

RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise ...

The aim of this review is to clarify exercise influence on bone modeling and remodeling, with a concentration on its role in regulating RANKL/RANK/OPG ...

Biology of RANK, RANKL, and osteoprotegerin

... role of the RANKL/RANK/OPG system in bone and other tissues ... functions beyond bone remodeling. RANKL/RANK signaling regulates the ...

Role of RANKL–RANK/osteoprotegerin molecular complex in bone ...

[2930] However, the administration of recombinant RANK (rRANK) in these animal models reinstates the process of osteoclastogenesis. At the same time, RANKL is a ...

RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise ...

Therefore, the aim of this review is to clarify exercise influence on bone modeling and remodeling, with a concentration on its role in ...

Bone remodeling: an operational process ensuring survival and ...

Bone modeling, remodeling, and the mutual regulation of bone resorption and formation ... Functions of RANKL/RANK/OPG in bone modeling and ...

The role of the serum RANKL/OPG ratio in the healing of ...

Following binding to RANKL, OPG inhibits bone resorption caused by osteoclasts and increases bone formation (12,13). Therefore, a number of ...

RANK, RANKL and osteoprotegerin in bone biology and disease

Upon the discovery of RANK, RANKL and OPG in the late 1990s, their importance in the maintenance of the skeletal structure and their ...

Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin ...

Osteoclast activity is likely to depend, at least in part, on the relative balance of RANKL and OPG. Studies in numerous animal models of bone disease show that ...

Osteoclast Differentiation and Bone Disease: The RANKL Angle

remodeling. Future research efforts are needed to illuminate the roles of RANKL/RANK/OPG pathway in these alternate organ systems in health and disease ...

Molecular Pathways: Osteoclast-Dependent and ... - AACR Journals

Knockout mice lacking either RANK or RANKL develop significant osteopetrosis resulting from a lack of osteoclasts and absence of bone resorption (1, 2). OPG ( ...