GPCR heteromers

GPCR heteromers: An overview of their classification, function and ...

GPCR heteromers represent novel drug targets with extensive therapeutic potential. Changes to ligand affinity, efficacy and G protein coupling have all been ...

GPCR heteromers: An overview of their classification, function and ...

G protein-coupled receptors (GPCRs) are capable of interacting to form higher order structures such as homomers and heteromers.

Pharmacological targeting of G protein-coupled receptor heteromers

Abstract. A main rationale for the role of G protein-coupled receptor (GPCR) heteromers as targets for drug development is the putative ability of selective ...

Quaternary structure of a G-protein-coupled receptor heterotetramer ...

Studies in a broad spectrum of GPCRs [11–14] show that these receptors may form heteromers. GPCR heteromers are defined as novel signaling ...

G Protein-Coupled Receptor Heteromer Identification Technology

The G protein-coupled receptor heteromer identification technology (GPCR-HIT) is a novel approach to identify and profile heteromers and the ligands that act ...

Evidence for functional pre-coupled complexes of receptor ... - Nature

It is becoming accepted that GPCRs can form heteromers, defined as macromolecular complexes composed of at least two different protomers with ...

Molecular mechanisms of GPCR heteromers signaling - ANR

G Protein Coupled Receptors (GPCRs) are key mediators of how cells sense and react to their outside environment. Traditionally, these receptors have been ...

Unveiling the complexity of G protein-coupled receptor heteromers

In addition, we discuss recent advances in live cell imaging techniques for exploring functional features of GPCR heteromers, for example, ...

GPCR oligomer - Wikipedia

Receptor heterodimers – which consist of two different GPCRs – are the simplest heteromeric GPCR oligomers. ... "GPCR heteromers and their allosteric receptor- ...

G Protein–Coupled Receptor Heteromers - Annual Reviews

G protein–coupled receptors (GPCRs) compose one of the largest families of membrane proteins involved in intracellular signaling. They are involved in ...

Interclass GPCR heteromerization affects localization and trafficking

Our data suggest that GPCR heteromerization may itself represent a mechanism of receptor trafficking and sorting.

Neuroprotection afforded by targeting G protein-coupled receptors in ...

... GPCR heteromer, and therefore new drugs can be developed with heteromers in mind. ... GPCRs in heteromers (GRiH) of heteromers themselves ...

G‐protein‐coupled receptor heteromers or how neurons can display ...

It is becoming accepted that G-protein-coupled receptors (GPCRs) arrange in the neuronal membrane into homo- and hetero-oligomers and, ...

History and Biological Significance of GPCR Heteromerization in the ...

The present review will give a brief history of GPCR oligomerization and emphasize the importance and physiological relevance of GPCR heteromerization.

Constraints on GPCR Heterodimerization Revealed by the Type-4 ...

∙ Pfleger, K.D.. G protein-coupled receptor heteromer identification technology: identification and profiling of GPCR heteromers. J. Lab ...

Science Signaling Podcast for 12 January 2016: GPCR heteromers ...

Abstract. This Podcast features an interview with Javier González-Maeso, author of a Research Article that appears in the 12 January 2016 issue of Science ...

Understanding the Added Value of G‐Protein‐Coupled Receptor ...

The future of GPCRs research is surely based on their capacity for heteromerization. Receptor heteromers offer a series of challenges that will ...

CODA-RET reveals functional selectivity as a result of GPCR ...

Based on a BRET readout, dopamine D2 receptor agonist NPA is more potent at activating Gαi when the D2 receptor forms a heteromer with the ...

GPCR & Their heteromers - gpcr therapeutics

It has been reported that a variety of GPCRs form heteromers. Heteromerization is now accepted as a general characteristic of GPCRs.

G protein-coupled receptor heteromer identification technology

The potential for unique pharmacology attributed to these GPCR complexes has opened up the possibility of a new class of targets that can be exploited for drug ...