Gene Expression Assay for Targeted Treatment

Gene Expression Detection Assay for Cancer Clinical Use - PMC

Therefore, detecting gene expression levels can be used for cancer diagnosis, prognosis, and treatment prediction in a clinical setting. In this review, we ...

Gene Expression Assay Shows Ability to Guide Targeted Treatment ...

Patients with cancers of unknown primary had more treatment options and better outcomes when care was informed by a 90-gene expression ...

Gene Expression Profiling as a Potential Tool for Precision ...

Current biomedical research is focused on developing treatments that specifically target abnormally activated regulatory pathways of cancer ...

Amplifying gene expression with RNA-targeted therapeutics - Nature

Protein replacement and gene therapy can achieve the goal of increased protein expression but have limitations. Recent discoveries of the ...

The clinical utility of the 90-gene expression assay on diagnosis and ...

A randomized phase III trial (CUP001) has demonstrated that site-specific treatment guided by the 90-gene-expression assay (Canhelp-Origin Assay) ...

Breast Cancer Gene Expression Tests | Tailor Your Treatment

This test looks at a set of 21 genes in cancer cells from tumor biopsy or surgery samples to get a “recurrence score,” which is a number between 0 and 100. The ...

Cancer Research using TaqMan Gene Expression Assays and Arrays

Genomic techniques for biomarker discovery can pave the way for identifying biomarkers that may serve as indicators for prediction, prognosis, and treatment of ...

Gene expression based inference of cancer drug sensitivity - Nature

Recently, the availability of high-throughput screening datasets has paved the way for machine learning based personalized therapy ...

QuantiGene Plex Gene Expression Assay - Thermo Fisher Scientific

Analyze 80 cytokine, chemokine, and growth factor RNA targets simultaneously for efficient immune response profiling, biomarker discovery, and validation. Learn ...

Development and Clinical Validation of a 90-Gene Expression ...

Findings suggest that this novel gene expression assay could efficiently predict the primary origin for a broad spectrum of tumor types and support its ...

Site-specific therapy guided by a 90-gene expression assay versus ...

This single-centre randomised trial showed that site-specific therapy guided by the 90-gene expression assay could improve progression-free ...

Targeted RNA Sequencing | Focus on specific transcripts of interest

Targeted RNA-Seq can be achieved via either enrichment or amplicon-based approaches, both of which enable gene expression analysis in a focused set of genes of ...

Microarray-Based Gene Expression Profiling for Molecular ...

Furthermore, careful examination of microarray-based gene expression profiles may identify new molecular targets (or pathways) for the development of targeted ...

Actionable Gene Expression-Based Patient Stratification for ... - PLOS

Efficacy of molecular targeted therapies has been better in cancer patients with high expression of actionable molecules defined as cognate target molecules.

Analyzing Tumor RNA to Improve Cancer Precision Medicine - NCI

A novel approach to analyzing gene expression in tumors may bring precision cancer medicine to more patients ... gene or genes targeted by each ...

Prospective Validation of a 21-Gene Expression Assay in Breast ...

Prior studies with the use of a prospective–retrospective design including archival tumor samples have shown that gene-expression assays ...

Molecular profiling for precision cancer therapies | Genome Medicine

An additional genomic tool in cancer are genomic “profiles” that harbor similar patterns of gene expression or of inherited or somatic mutations ...

Implementation of a High-Accuracy Targeted Gene Expression ...

Concordance between high gene expression and gene copy number gain varied by specific gene, and some genes had higher accuracy between assays. Clinical ...

Site-Specific and Targeted Therapy Based on Molecular Profiling by ...

Interventions RNA and DNA sequencing for selected genes was performed simultaneously to evaluate gene expression and gene alterations, ...

Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in ...

The recurrence score based on the 21-gene breast cancer assay predicts chemotherapy benefit if it is high and a low risk of recurrence in the absence of ...