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Gene variant linked to statin side effect


Gene variant linked to statin side effect - NBC News

Gene variant linked to statin side effect ... Scientists may have found a way to test for and possibly avoid the most serious side effect of ...

The SLCO1B1*5 Genetic Variant is Associated with Statin-Induced ...

SLCO1B1*5 genotype and female sex were associated mild statin-induced side effects. These findings expand the results of a recent genome wide association study.

Role of genetics in the prediction of statin-associated muscle ...

Variation in the ABCB1 gene has been reported to be associated with myalgia. ... Variation in ABCG2 impacts the plasma concentrations of statins, in particular, ...

Genetic Testing for Statin-Induced Myopathy - Bynder

[2] Other genetic variants affect statin metabolism, efficacy, and susceptibility to adverse ... due to suspected side effects (73 ...

The Gene That Explains Statins' Most Puzzling Side Effect

Recently, two groups of scientists stumbled upon an answer. They didn't set out to study statins. They weren't studying cholesterol at all. They ...

23andMe Releases New FDA-Cleared Genetic Report on ...

Having one or two copies of the SLCO1B1 variant included in 23andMe's report increases the risk of developing simvastatin-associated myopathy, ...

Muscle problems caused by statins: Can a genetic test reveal your ...

In the study used to validate StatinSmart's genetic test, the researchers defined myopathy as symptoms of myalgia (muscle pain) in addition to a ...

The SLCO1B1*5 genetic variant is associated with statin-induced ...

BACKGROUND: Statin-induced side effects can interfere with therapy. Single nucleotide polymorphisms in cytochrome P450 enzymes impair statin metabolism; the ...

Systematic Review Genetic factors affecting statin concentrations ...

All statins were included in this review. Among the genetic factors evaluated, statin-related myopathy appears to be most strongly associated with variants in ...

Common Statin Intolerance Variants in ABCB1 and LILRB5 Show ...

Conclusion: We report two genetic variants for statin adverse drug reactions (ADRs) that are associated with statin efficacy. While the ABCB1 variant has been ...

Study offers hope of reducing statin side-effects - University of Dundee

Certain genetic variations or factors in the gene that produces this protein can affect its activity, leading to differences in the ...

Gene Variant May Increase Risk for Rare Side Effect of Cholesterol ...

When these people were compared to 90 people who were on high-dose simvastatin but had no signs of muscle problems, the researchers found that ...

Pharmacogenomic Study of Statin-Associated Muscle Symptoms in ...

Previous studies have reported an association between the p.Val174Ala missense variant in SLCO1B1 and SAMS in simvastatin-treated subjects; ...

The SLCO1B1*5Genetic Variant Is Associated With Statin-Induced ...

Statin-induced side effects can interfere with therapy. Single nucleotide polymorphisms in cytochrome P450 enzymes impair statin metabolism; the reduced ...

Pharmacogenetics of Statin-Induced Myotoxicity - Frontiers

Statin-induced myotoxicity presents as fatigue, muscle pain, muscle tenderness, muscle weakness, nocturnal cramping, or tendon pain (Sathasivam and Lecky, 2008) ...

Statin Toxicity | Circulation Research - AHA Journals

In addition to variants in SLCO1B1, an intronic variant in RYR2 gene, rs2819742, was identified as being linked with rhabdomyolysis associated ...

Review The genetics of statin-induced myopathy - ScienceDirect.com

Furthermore, individuals with genetic variants of the SLCO1B1 gene, which encodes for the organic anion transporter and thereby affects statin hepatic uptake, ...

Genetic test helps people avoid statins that may cause them pain

A variant of this gene has been linked to aches in response to statins. ... affects what side effects someone experiences from different statins ...

Genetic Testing May Improve Statin's Ability to Lower Cholesterol

For nearly a decade, researchers have been aware of the genetic variant that predisposes patients to statin side effects. Approximately 15% of ...

Pharmacogenomics of statins: understanding susceptibility to ...

Furthermore, a considerable number of patients experience adverse effects. Statin myositis and statin-associated muscle symptoms (SAMS) comprise ...