Generating Human Organs via Interspecies Chimera Formation

An alternative and promising strategy is to generate human organs inside large animal species through a technique called interspecies blastocyst ...

Towards human organ generation using interspecies blastocyst ...

In this regard, emerging technologies of chimeric human organ production via blastocyst complementation (BC) holds great promise. To take human ...

(PDF) Generating Human Organs via Interspecies Chimera Formation

An alternative and promising strategy is to generate human organs inside large animal species through a technique called interspecies blastocyst complementation ...

[PDF] Generating Human Organs via Interspecies Chimera Formation

It is proposed that further advances in the generation of chimera-competent human PS cells are needed to achieve interspecies blastocyst complementation, ...

New concepts for generating interspecies chimeras using human ...

As the chimeric embryo develops, donor cells can fill the vacated developmental organ niche and enrich in a target organ of interest. In ...

Interspecies chimeras - ScienceDirect.com

Thus, a human organ grown in a livestock animal could provide patient-matched organs and eliminate the organ transplant waiting list. This article will review ...

Interspecies Chimerism with Mammalian Pluripotent Stem Cells

Besides gaining insights into species evolution, embryogenesis, and human disease, interspecies blastocyst complementation might allow human organ generation in ...

Interspecies Chimeric Barriers for Generating Exogenic Organs and ...

By overcoming the interspecies chimera barriers and creating highly competent chimeras, the technology of organ and cellular generation can be ...

Generation of human-pig chimeric renal organoids using iPSC ...

Interspecies chimeric organ production using human iPSCs shows promise in overcoming these challenges. Our group successfully generated chimeric ...

The road to generating transplantable organs: from blastocyst ...

Summary: This Review summarizes the progress made in and roadblocks hindering the growth of human organs in animals via interspecies ...

Growth Competition in Interspecies Chimeras: A New Paradigm for ...

As the chimeric embryo develops, the emptied organ niche can be exclusively filled by xenogeneic donor cells. Since the first generation of a ...

Interspecies Organogenesis | Wu (Jun) Lab

Proof-of-concept studies in rodents have clearly indicated that the organs generated via interspecies blastocyst complementation are just as ...

Interspecies chimeras for human stem cell research | Development

The ability to contribute to chimera formation across multiple lineages when injected into the pre-implantation blastocyst is still a gold ...

Interspecies chimeras as a platform for exogenic organ production ...

One of the alternative therapies is the engineering of interspecies chimeric organs (Figure 1). One approach for the generation of interspecies chimeric organs ...

Chimeric Livers: Interspecies Blastocyst Complementation and ...

The technique is centered around the generation of cells and even whole organs of one animal species, the donor, through the use of another animal species in ...

Human-animal chimeras for autologous organ transplantation

Human-animal chimeras provide the ability to produce human organs in other species using autologous stem cells [e.g., induced pluripotent stem cells (iPSCs) or ...

Human–animal chimeras: ethical issues about farming chimeric ...

paved the way for the generation of interspecies chimeras, such as animals bearing an organ from another species. The production of a rat ...

Growth Competition in Interspecies Chimeras: A New Paradigm for ...

As the chimeric embryo develops, the emptied organ niche can be exclu- sively filled by xenogeneic donor cells. Since the first generation of a ...

Human-animal interspecies chimerism via blastocyst complementation

Objective: Interspecific human-animal chimerism via blastocyst complementation provides a promising strategy to generate function human cells, tissues or organs ...

An interspecies barrier to tetraploid complementation and chimera ...

To study development of the conceptus in xenogeneic environments, we assessed interspecies chimera formation as well as tetraploid ...