Generation of brain tumours in mice by Cre|mediated recombination ...

Generation of brain tumours in mice by Cre-mediated recombination ...

Targeted cell- or region-specific gene recombination is widely used in the functional analysis of genes implicated in development and ...

Generation of brain tumours in mice by Cre-mediated recombination ...

A single site-specific injection of an active derivative of tamoxifen successfully activates Cre recombinase and selectively recombines tumour suppressor ...

Generation of brain tumours in mice by Cre-mediated recombination ...

The use of the Cre-loxP system to study tumorigenesis in the adult central nervous system (CNS) can be limited, when the promoter (such as GFAP) ...

(PDF) Generation of brain tumours by Cre-mediated recombination ...

The use of the Cre-loxP system to study tumourigenesis in the adult CNS can be limited, when the promoter (such as GFAP) is also transiently ...

Generation of brain tumours by Cre-mediated recombination of ...

Engineering of transgenic mice expressing Cre recombinase fused to a mutant of the human oestrogen receptor (ER) allows the circumvention of transient ...

Inducing primary brainstem gliomas in genetically engineered mice ...

One technique for inducing primary tumors in these genetically engineered mice involves delivering viral vectors containing the code for gene- ...

A Cre-conditional MYCN-driven neuroblastoma mouse model as an ...

We here report on the generation of transgenic mice with Cre-conditional induction of MYCN in dopamine β-hydroxylase-expressing cells, termed LSL-MYCN;Dbh-iCre.

Targeting Self-Renewal in High-Grade Brain Tumors Leads to Loss ...

After introducing a BTSC-specific knock-out of the Tlx gene in primary mouse tumors, we observed a loss of self-renewal of BTSCs and ...

Genetically Engineered Mouse Models of Brain Cancer and the ...

Many of the GEMMs described thus far achieve their effects largely through the widespread expression of an oncogenic transgene across the brain.

The tumor suppressor CREBBP and the oncogene MYCN cooperate ...

Therefore, we hypothesized that alterations in both genes cooperate to induce brain tumor formation. For further investigation, hGFAP-cre:: ...

Mouse Models of Experimental Glioblastoma - Exon Publications

Most glioblastoma mouse models have used the Cre-LoxP system to target tumor genes in the specific brain tissue of interest (Figure 1A, B) (45).

In vivo mouse models for adult brain tumors - Oxford Academic

Large-scale genomic studies have facilitated the identification of genetic alterations driving human brain tumor development and progression.

Rapid Generation of Somatic Mouse Mosaics with Locus-Specific ...

Several independent EPs of the. HrasG12V donor plasmid and Cre recombinase alone failed to produce tumor formation when examined 2 weeks post-EP ...

CreERT2 - Taconic Biosciences

Successful ubiquitous induction of Cre activity after tamoxifen administration in all tissues analyzed. Efficiency of deletion varies between different organs ...

Characterized cre lines - The Jackson Laboratory

Cre recombinase activity is targeted to most astrocytes throughout the healthy brain and spinal cord and to essentially all astrocytes after Central Nervous ...

Combinations of genetic mutations in the adult neural stem cell ...

Figure 6. Recombinant astrocytes do not form brain tumours. In vitro recombined astrocytes (PTEN/Rb/p53) were implanted into the striatum of ...

Contemporary Mouse Models in Glioma Research - MDPI

Cre recombinase expression cassettes can be placed under the control of brain ... Brain Tumor Growth in Orthotopic Mouse Models. Int. J. Mol. Sci. 2018, 19 ...

Adeno-associated virus effectively mediates conditional gene ...

By using a reporter mouse, in which Cre recombinase activates β-galactosidase expression, we demonstrate long-term recombination of neurons in the hippocampus, ...

Modeling Brain Tumors: A Perspective Overview of in vivo and ...

Cre-lox is a gene-editing technology that allows site-specific recombination between sequences called Lox sites using the enzyme Cre recombinase. The action of ...

Current trends in mouse models of glioblastoma - SpringerLink

... generation of mouse models of interest in the study of brain tumors. ... mice expressing Cre-recombinase under varying promoters such as GFAP.