Genetic Instability and Transcriptional Regulation

Transcription-replication conflicts as a source of genome instability

Additionally, some long genes take more than one cell cycle to transcribe (49). Therefore, RNAPs persist on DNA throughout replication, but how ...

Genetic Instability and Transcriptional Regulation - IPBS-Toulouse

The major goal of our team is to decipher the molecular mechanisms underlying antibody diversification and their deregulation in B-cell cancers.

Impact of genome instability on transcription regulation of aging and ...

Genomic instability has been implicated as a major stochastic mechanism of aging. Using a transgenic mouse model with chromosomally integrated lacZ ...

Regulatory R-loops as facilitators of gene expression and genome ...

R-loop misregulation is associated with DNA damage, transcription elongation defects, hyper-recombination and genome instability. In contrast to ...

The connection between transcription and genomic instability

Papavasiliou FN and Schatz DG (2000) Cell‐cycle‐regulated DNA double‐stranded breaks in somatic hypermutation of immunoglobulin genes Nature, 408, 216–221.

Transcription–Replication Conflicts as a Source of Genome Instability

Transcription and replication both require large macromolecular complexes to act on a DNA template, yet these machineries cannot ...

Genome Instability - an overview | ScienceDirect Topics

A direct consequence of genomic instability is cell cycle stress, changes in gene expression and changes in gene regulation. Ultimately, this could explain age- ...

Special Issue : Transcription-Associated Genetic Instability - MDPI

The essential process of gene expression poses a threat to the integrity of the genome. As was first observed in the early 1980s both in prokaryotes and ...

DNA damage and transcription stress

... regulate the initiation and progression of gene transcription. ... TRANSCRIPTIONAL STRESS, GENOME INSTABILITY,. AND CANCER. In addition ...

More than causing (epi)genomic instability: emerging physiological ...

Both transcriptional and posttranscriptional pathways are involved in TE regulation. The consummate management of TEs is presumably performed ...

The impact of transcription-mediated replication stress on genome ...

Growing evidence shows that gene transcription has an essential role in shaping the landscape of genome replication, while it is also a major ...

Microsatellite instability regulates transcription factor binding ... - PNAS

Here we report that loss or gain of TAAA repeats affects the binding of the transcriptional regulatory protein IHF to the nadA promoter.

Review DNA damage and transcription stress - ScienceDirect.com

While in some contexts DNA damage and transcription work synergistically to regulate gene expression, very often, they are in conflict and ...

a crosstalk between genomic stability and epigenetic control? - Nature

These alterations influence gene expression as well as regulation of heterochromatin regions impacting on genomic instability [18]. DNA repair ...

Genetic instability associated with loop or stem–loop structures ...

For these structures, all unpaired DNA loops and DNA stem–loops impeded transcription elongation in vitro, but to varying extents. DNA stem–loops appeared to be ...

Introns Protect Eukaryotic Genomes from Transcription-Associated ...

Transcription is a source of genetic instability that can notably result from the formation of genotoxic DNA:RNA hybrids, or R-loops, between the nascent ...

Transcription-coupled genetic instability marks acute lymphoblastic ...

We present signal feature analysis to detect vulnerable regions and quantified from human cells how convergent transcription contributes to R- ...

Selective defects in gene expression control genome instability in ...

Here we characterize genome instability phenotypes in yeast splicing factor mutants and find that mitotic defects, and in some cases R-loop ...

Maf1‐dependent transcriptional regulation of tRNAs prevents ...

We propose that Maf1-dependent inhibition of tRNA synthesis controls fission yeast lifespan by preventing genomic instability that arises at ...

Integrated genome and transcriptome analyses reveal the ... - PNAS

Genome instability was caused by increased transcription stress and the accumulation of RNA/DNA hybrids near gene promotors, resulting in aberrant DNA repair ...