Genetic Variants Associated With Cancer Therapy

Genetic Variants Associated With Cancer Therapy–Induced ...

Genetic Variants Associated With Cancer Therapy-Induced ...

Unrecognized rare variants in cardiomyopathy-associated genes, particularly TTNtvs, increased the risk for CCM in children and adults, and adverse cardiac ...

Genetic Variants Associated With Cancer Therapy–Induced ...

Unrecognized rare variants in cardiomyopathy-associated genes, particularly TTNtvs, increased the risk for CCM in children and adults, and adverse cardiac ...

Genetic Variants Associated With Cancer Therapy–Induced ...

Cancer therapy–induced cardiomyopathy (CCM) is associated with cumulative drug exposures and preexisting cardiovascular disorders. These ...

Genetics of Cancer Therapy-Associated Cardiotoxicity - PMC - NCBI

Genetic variants in a gene family of soluble carriers (SLCs) also show a protective influence on anthracycline-induced cardiomyopathy. These ...

Genetic Variants Associated With Cancer Therapy-Induced ...

The prevalence of rare variants was compared between CCM cohorts and The Cancer Genome Atlas participants (n=2053), healthy volunteers (n=445), and an ancestry- ...

Genetics of cancer therapy-associated cardiotoxicity - ScienceDirect

Pathogenic variants in the genes encoding proteins that comprise sarcomeres also contribute to cardiomyopathy following cancer therapies. Furthermore, genetic ...

Genetics of cancer therapy-induced cardiomyopathy - Nature

In a study published in Circulation, Garcia-Pavia and colleagues report an increased prevalence of rare variants of cardiomyopathy-related genes ...

Variants in structural cardiac genes in patients with cancer therapy ...

Variants in cardiomyopathy genes have been identified in patients with cancer therapy-related cardiac dysfunction (CTRCD), suggesting a ...

Potential Gene Association Studies of Chemotherapy-Induced ...

The results of our meta-analysis showed that the polymorphisms in six (6.8%) of eighty-eight genes were obviously associated with the risk of ...

Genetic Variants Associated with Therapy-Related Cardiomyopathy ...

Childhood cancer survivors of African ancestry are at higher risk of cardiomyopathy than those of European ancestry, and a novel locus at 1p13.2 is.

Genetic Factors Involved in Cardiomyopathies and in Cancer - MDPI

Genetic variants in germinal cells that cause CMY (LMNA, RAS/MAPK) can increase susceptibility for certain types of cancer.

The genetic variants underlying breast cancer treatment-induced ...

Three out of 5 studies found an association between HER2 lle655Val polymorphisms and trastuzumab-induced cardiotoxicity. Two studies found a positive ...

Genetic variants associated with carboplatin-induced cytotoxicity in ...

Several genetic polymorphisms within candidate genes have been shown to correlate with clinical response to carboplatin. For example, XRCC1 R399Q is associated ...

(PDF) Genetic Variants Associated With Cancer Therapy-Induced ...

Chemotherapy-induced cardiomyopathy (CCM) can present as reduced LVEF with or without signs and symptoms of overt HF [45, 46] . CCM is linked to ...

Genetic Variants Associated With Cancer Therapy–Induced ...

BACKGROUND:Cancer therapy–induced cardiomyopathy (CCM) is associated with cumulative drug exposures and preexisting cardiovascular disorders.

Genetic variant linked to chemotherapy-induced cardiomyopathy

Truncating variants in the TTN gene (TTNtv) were found in 7.5% of the 213 patients with CCM who were recruited from three different cancer ...

Genetic Variants Associated With Cancer Therapy–Induced ...

BACKGROUND:Cancer therapy–induced cardiomyopathy (CCM) is associated with cumulative drug exposures and preexisting cardiovascular disorders.

Genetic Variants Associated With Cancer Therapy-Induced ...

Genotype, along with cumulative chemotherapy dosage and traditional cardiovascular risk factors, improves the identification of patients who ...

Genetics of Anthracycline-Associated Cardiotoxicity - Frontiers

Genetic Variants Associated With Cancer Therapy-Induced Cardiomyopathy. Circulation. (2019) 140:31–41. doi: 10.1161/CIRCULATIONAHA ...

Genetic predisposition in chemotherapy‐induced cardiomyopathy in ...

The prevention and management of cancer therapy-related cardiac dysfunction (CTRCD) have become increasingly important.