Genetic studies of Crohn's disease

Crohn's disease - Genetics - MedlinePlus

Crohn's disease is a complex, long-lasting (chronic) disorder that primarily affects the digestive system.

Genetic studies of Crohn's disease: Past, present and future - NCBI

We review the history of gene-mapping studies of Crohn's disease, from the linkage-based studies that first implicated the NOD2 locus, through to modern-day ...

Role of genetics in the diagnosis and prognosis of Crohn's disease

CARD15 explains around 20% of the genetic predisposition to Crohn's disease[64]. The relative risk of developing CD in the presence of one mutation is 2-4, but ...

A systematic review and functional bioinformatics analysis of genes ...

In fact, heritability estimates for Crohn's disease from pooled twin studies have been reported to be 0.75 [7]. As with many other complex ...

Large-scale sequencing identifies multiple genes and rare variants ...

Genome-wide association studies (GWASs) have identified hundreds of loci associated with Crohn's disease (CD). However, as with all complex ...

Is Crohn's disease genetic? Causes, testing, and more

Researchers do not know exactly why Crohn's disease develops in some people, but genetic factors seem to play a role.

Study zeroes in on genes involved in Crohn's disease

An international consortium of researchers has identified genetic variants in 10 genes that elevate a person's susceptibility to Crohn's ...

Large sequencing effort links new genes to Crohn's disease risk

Six of those genes had no previous links to the disorder, and four are in regions of the genome that other studies had linked to Crohn's disease ...

Causes of Crohn's Disease

Recent research suggests hereditary, genetic, and environmental factors contribute to Crohn's disease development. Crohn's Disease and the Immune System. A ...

Is Crohn's Disease Genetic? Statistics and More - Healthline

Yes, genetics do appear to play a role in Crohn's disease, though other environmental factors may also be involved.

About Crohn's Disease - National Human Genome Research Institute

About 20 percent (1 in 5) of people who have Crohn's disease have a blood relative with some form of inflammatory bowel disease, usually a ...

Inflammatory Bowel Disease: Genetics, Epigenetics, and ... - Frontiers

Population-based studies have provided compelling evidence that genetic factors contribute to the pathogenesis of IBD; an 8- to 10-fold greater risk of IBD ...

The Genetics of Inflammatory Bowel Disease

Simplified, first-degree relatives of patients with CD have an eight-fold higher risk of developing IBD, while first-degree relatives of ...

Inherited determinants of Crohn's disease and ulcerative colitis ...

Genetic studies have identified 163 susceptibility loci for inflammatory bowel disease, mostly shared between Crohn's disease and ulcerative ...

Crohn's disease risk and prognosis determined by different genes ...

“Genetic studies have been very successful at identifying genetic risk factors for Crohn's disease, but have told us virtually nothing about why ...

Genetic and Epigenetic Etiology of Inflammatory Bowel Disease

Most of the evidence for an association between this genetic variant and the etiology of IBD comes from functional studies using the variant ATG16L1 T300A. The ...

Genetic Complexity of Crohn's Disease in Two Large Ashkenazi ...

Crohn's disease (CD) is a highly heritable disease that is particularly common in the Ashkenazi Jewish population. We studied 2 large Ashkenazi Jewish families ...

A Convergent Study of Genetic Variants Associated With Crohn's ...

Many high-throughput omics studies have been conducted to identify disease associated risk variants that might contribute to CD, such as genome-wide association ...

Genetic Studies of Inflammatory Bowel Disease-Focusing on Asian ...

Impaired genetic regulation of the innate immune response to the normal flora is a key mechanism in the etiology of CD and UC as gene mutations, such as NOD2/ ...

Major cause of Inflammatory Bowel Disease discovered

Researchers at the Francis Crick Institute have found a major new cause of Inflammatory Bowel Disease (IBD). Using genetic analysis, the ...