Genome|wide analysis of genetic pleiotropy and causal genes ...

Genome-wide analysis of genetic pleiotropy and causal genes ...

Age-related macular degeneration (AMD), cataract, and glaucoma are leading causes of blindness worldwide. Previous genome-wide association studies (GWASs) ...

Genome-wide analysis of genetic pleiotropy and causal genes ...

We found that pleiotropic genes were essential in nerve development and eye pigmentation, and targetable by aflibercept and pilocarpine for the treatment of ...

Genome-wide analysis of genetic pleiotropy and causal genes ...

We undertook meta-analyses with the largest GWAS summary statistics of these ocular disorders to identify pleiotropic loci. We then ...

Genome-wide analysis of genetic pleiotropy and causal genes ...

This study aims to identify genetic pleiotropic genes among AMD, cataract, and glaucoma. Methods. We leveraged large-scale genetic and observational data from ...

Prediction of causal genes at GWAS loci with pleiotropic ... - NCBI

Indeed, most genetic variants associated to mRNA and protein abundances (and phenotypic traits) are located in non-coding regions of the genome ...

Genetic analyses identify pleiotropy and causality for blood proteins ...

Pleiotropy analyses link 58 blood proteins to migraine risk at genome-wide, gene and/or single-nucleotide polymorphism levels—suggesting shared ...

GWAS Publication 36917350 - EMBL-EBI

Publication: Genome-wide analysis of genetic pleiotropy and causal genes across three age-related ocular disorders.

Genome-wide large-scale multi-trait analysis characterizes global ...

There has been a long quest in genetics to characterize the degree and nature of pleiotropy for complex traits. Early population genetic models ...

Genetic pleiotropy in complex traits and diseases - Genome Medicine

Pleiotropy is the phenomenon in genetics whereby a DNA variant influences multiple traits. We have known for decades that pleiotropy is widespread.

Phenome-wide search for pleiotropic loci highlights key genes and ...

... wide significance and genetic pleiotropy across the human phenome based on GWAS summary statistics. ... causal effects between genetic ...

Evaluating the potential role of pleiotropy in Mendelian ...

epidemiologic causality; genetics; pleiotropism; genome-wide association study; mendelian randomization analysis. Issue Section:.

Prediction of causal genes at GWAS loci with pleiotropic ... - arXiv

Traditionally MR is used to study phenotypic traits where genetic ... “A comprehensive 1,000 Genomes-based genome-wide association meta-analysis ...

Mendelian randomization for causal inference accounting ... - PNAS

Mendelian randomization for causal inference accounting for pleiotropy and sample structure using genome-wide summary statistics ... genome-wide genetic ...

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid ...

A recent wide-ranging Mendelian randomization analysis confirmed the causal ... The power of genetic diversity in genome-wide association studies ...

A scalable approach to characterize pleiotropy across thousands of ...

Summary. Genome-wide association studies (GWASs) across thousands of traits have revealed the pervasive pleiotropy of trait-associated genetic variants. While ...

Modeling of horizontal pleiotropy identifies possible causal gene ...

While genome-wide association studies (GWASs) have identified genetic ... analysis for the causal effects of expressions of four genes on SLE.

Genome-wide analysis of genetic pleiotropy and causal genes ...

Genome-wide analysis of genetic pleiotropy and causal genes across three age-related ocular disorders ... Authors: Xueming Yao; Hongxi Yang; Han Han; Xuejing Kou ...

PLEIO: a method to map and interpret pleiotropic loci with GWAS ...

Our method starts by estimating the genetic correlations, environmental correlations, and heritability for each trait from the whole-genome GWAS summary ...

Huge genetic study on pleiotropy and genetics of complex traits

The study is published in Nature Genetics. A decade of genome-wide association studies (GWAS) has provided a wealth of genetic associations for ...

Genome-wide pleiotropy analysis of coronary artery disease and ...

Tissue-specific causal effects of the expression of ADAMTS7 and IL6R gene on CAD and pneumonia. Mendelian randomization with inverse variance– ...