Genome‐wide association studies in Crohn's disease

Genome‐wide association studies in Crohn's disease - NCBI

A genome‐wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1.

Large-scale sequencing identifies multiple genes and rare variants ...

Genome-wide association studies (GWASs) have identified hundreds of loci associated with Crohn's disease (CD). However, as with all complex ...

Genome-wide association study identifies distinct genetic ... - Nature

... and colleagues report a within-cases genome-wide association analysis for Crohn's disease ... genome-wide association studies (GWAS) in ...

Genome-wide association studies in Crohn's disease - PubMed

Over the course of the past decade, genome-wide association studies (GWAS) have revolutionised our understanding of complex disease genetics.

Genetic studies of Crohn's disease: Past, present and future

In the 140 loci associated with Crohn's risk, the number of SNPs that are tagged (r2 > 0.8) by the main GWAS SNP range from 1 to 306 per locus ( ...

Large sequencing effort links new genes to Crohn's disease risk

Genome-wide association studies (GWAS) have implicated common variants and regions of the genome, or loci, in Crohn's, but most of the ...

Genome-wide association study for Crohn's disease in the ... - PNAS

Genome-wide association (GWA) studies offer a powerful unbiased method for the identification of multiple susceptibility genes for complex diseases.

OP11 Expanded genome-wide association study of Inflammatory ...

Genome-wide association studies (GWASs) have identified 243 loci associated with inflammatory bowel disease (IBD). However, the mapping of ...

Genome-wide association study of Crohn's disease in Koreans ... - Gut

Meta-analyses of genome-wide association studies (GWAS) in Caucasian populations identified 140 Crohn's disease (CD) susceptibility loci. Considerable ...

OP08 Multi-ancestry genome-wide association study of inflammatory ...

AbstractBackground. Genome-wide association studies (GWASs) have identified 320 loci associated with inflammatory bowel disease (IBD).

s disease - GWAS Catalog

The NHGRI-EBI GWAS Catalog: a curated collection of all published genome-wide association studies, produced by a collaboration between EMBL-EBI and NHGRI.

Identification of Risk Loci for Crohn's Disease Phenotypes Using a ...

Crohn's disease is a highly heterogeneous inflammatory bowel disease comprising multiple clinical phenotypes. Genome-wide association studies (GWASs) have ...

Genome-Wide Association Studies in Inflammatory Bowel Disease

▫ association analyses using Cochran-Armitage trend tests. Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's ...

Diverse Genome-wide Association Studies Associate the IL12/IL23 ...

Here, we applied pathway analysis using Affymetrix SNP genotype data from the Wellcome Trust Case Control Consortium (WTCCC) and uncovered ...

Genome‐wide association studies in Crohn's disease: Past, present ...

Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease. Nat Genet 2017; 49: ...

Transcriptome-wide association studies associated with Crohn's ...

on genome-wide association studies (GWAS) and gene expression data, transcriptome-wide association studies ... inflammatory bowel disease ...

A Genome-Wide Association Study Identifies 2 Susceptibility Loci for ...

Crohn's disease is an inflammatory bowel disease induced by multiple genetic and environmental factors. Genome-wide association studies have identified ...

Multivariate genome-wide association study models to improve ...

Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) that affects the gastrointestinal tract with diverse symptoms. At present, genome-wide ...

A Convergent Study of Genetic Variants Associated With Crohn's ...

Many high-throughput omics studies have been conducted to identify disease associated risk variants that might contribute to CD, such as genome-wide association ...

OP14 Interpreting genome-wide association studies of Inflammatory ...

Inflammatory bowel disease (IBD) is a complex disease characterised by chronic inflammation of the digestive tract. Genome-wide association studies (GWAS) have ...